LOCUS       SIT98352.1               182 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            IRON-REGULATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A PPIA
            (PPIase A) (ROTAMASE A) protein.
ACCESSION   LT708304-9
PROTEIN_ID  SIT98352.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ppiA"
                     /locus_tag="BQ2027_MB0009"
                     /standard_name="cfp22"
                     /note="Mb0009, ppiA, len: 182 aa. Equivalent to Rv0009,
                     len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 182 aa overlap). Probable ppiA
                     (alternate gene name: cfp22), iron-regulated
                     peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8),
                     equivalent to NP_301138.1|NC_002677 putative
                     peptidyl-prolyl cis-trans isomerase from Mycobacterium
                     leprae (182 aa), FASTA score: (90.1% identity in 182 aa
                     overlap). Also highly similar to others e.g. T36725 from
                     Streptomyces coelicolor (177 aa); T43805 from
                     Halobacterium salinarum (180 aa); NP_219383.1|NC_000919
                     from Treponema pallidum (215 aa); etc. BELONGS TO THE
                     CYCLOPHILIN-TYPE PPIASE FAMILY. Alternative start codon
                     has been suggested. Protein product from Mb0009 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0009 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65763"
                     /db_xref="InterPro:IPR002130"
                     /db_xref="InterPro:IPR020892"
                     /db_xref="InterPro:IPR024936"
                     /db_xref="InterPro:IPR029000"
                     /db_xref="UniProtKB/Swiss-Prot:P65763"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MADCDSVTNS PLATATATLH TNRGDIKIAL FGNHAPKTVA NFVGLAQGTK DYSTQNASGG
       61 PSGPFYDGAV FHRVIQGFMI QGGDPTGTGR GGPGYKFADE FHPELQFDKP YLLAMANAGP
      121 GTNGSQFFIT VGKTPHLNRR HTIFGEVIDA ESQRVVEAIS KTATDGNDRP TDPVVIESIT
      181 IS
//