LOCUS       SIT98343.1               714 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 DNA
            GYRASE (SUBUNIT B) GYRB (DNA TOPOISOMERASE (ATP-HYDROLYSING)
            ) (DNA TOPOISOMERASE II) (TYPE II DNA TOPOISOMERASE) protein.
ACCESSION   LT708304-5
PROTEIN_ID  SIT98343.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gyrB"
                     /locus_tag="BQ2027_MB0005"
                     /note="Mb0005, gyrB, len: 714 aa. Equivalent to Rv0005,
                     len: 714 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.9% identity in 714 aa overlap). gyrB, DNA gyrase
                     subunit B (EC 5.99.1.3) (see citations below), equivalent,
                     except in N-terminus, to other Mycobacterial DNA GYRASES
                     SUBUNIT B e.g. T10005 from Mycobacterium leprae (697 aa);
                     Q9L7L3|GYRB_MYCPA from Mycobacterium avium subsp.
                     paratuberculosis (677 aa) (has its N-terminus shorter);
                     P48355|GYRB_MYCSM from Mycobacterium smegmatis (675 aa);
                     etc. Also highly similar to others e.g. T10969 from
                     Streptomyces coelicolor (686 aa); P50075|GYBS_STRSH from
                     Streptomyces spheroides (684 aa); etc. Contains PS00177
                     DNA topoisomerase II signature. BELONGS TO THE TYPE II
                     TOPOISOMERASE FAMILY. Protein product from Mb0005 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0005 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XU15"
                     /db_xref="InterPro:IPR001241"
                     /db_xref="InterPro:IPR002288"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR011557"
                     /db_xref="InterPro:IPR013506"
                     /db_xref="InterPro:IPR013759"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR018522"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="InterPro:IPR034160"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU15"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MGKNEARRSA LAPDHGTVVC DPLRRLNRMH ATPEESIRIV AAQKKKAQDE YGAASITILE
       61 GLEAVRKRPG MYIGSTGERG LHHLIWEVVD NAVDEAMAGY ATTVNVVLLE DGGVEVADDG
      121 RGIPVATHAS GIPTVDVVMT QLHAGGKFDS DAYAISGGLH GVGVSVVNAL STRLEVEIKR
      181 DGYEWSQVYE KSEPLGLKQG APTKKTGSTV RFWADPAVFE TTEYDFETVA RRLQEMAFLN
      241 KGLTINLTDE RVTQDEVVDE VVSDVAEAPK SASERAAEST APHKVKSRTF HYPGGLVDFV
      301 KHINRTKNAI HSSIVDFSGK GTGHEVEIAM QWNAGYSESV HTFANTINTH EGGTHEEGFR
      361 SALTSVVNKY AKDRKLLKDK DPNLTGDDIR EGLAAVISVK VSEPQFEGQT KTKLGNTEVK
      421 SFVQKVCNEQ LTHWFEANPT DSKVVVNKAV SSAQARIAAR KARELVRRKS ATDIGGLPGK
      481 LADCRSTDPR KSELYVVEGD SAGGSAKSGR DSMFQAILPL RGKIINVEKA RIDRVLKNTE
      541 VQAIITALGT GIHDEFDIGK LRYHKIVLMA DADVDGQHIS TLLLTLLFRF MRPLIENGHV
      601 FLAQPPLYKL KWQRSDPEFA YSDRERDGLL EAGLKAGKKI NKEDGIQRYK GLGEMDAKEL
      661 WETTMDPSVR VLRQVTLDDA AAADELFSIL MGEDVDARRS FITRNAKDVR FLDV
//