LOCUS       SIT98333.1               507 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CHROMOSOMAL
            REPLICATION INITIATOR PROTEIN DNAA protein.
ACCESSION   LT708304-1
PROTEIN_ID  SIT98333.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dnaA"
                     /locus_tag="BQ2027_MB0001"
                     /note="Mb0001, dnaA, len: 507 aa. Equivalent to Rv0001,
                     len: 507 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 507 aa overlap). dnaA, chromosomal
                     replication initiator protein (see citations below),
                     equivalent to other Mycobacterial CHROMOSOMAL REPLICATION
                     INITIATOR PROTEINS e.g. P46388|DNAA_MYCLE from
                     Mycobacterium leprae (502 aa); Q9L7L7|DNAA_MYCPA from
                     Mycobacterium paratuberculosis (509 aa); P49990|DNAA_MYCAV
                     from Mycobacterium avium (508 aa); P49992|DNAA_MYCSM from
                     Mycobacterium smegmatis (504 aa); etc. Also highly similar
                     to others except in N-terminus e.g. Q9ZH75|DNAA_STRCH
                     CHROMOSOMAL REPLICATION INITIATOR PROTEIN from
                     Streptomyces chrysomallus (624 aa); Q9ZH76|DNAA_STRRE from
                     Streptomyces reticuli (643 aa); DNAA_ECOLI|P03004|B3702
                     chromosomal replication initiator protein from Escherichia
                     coli strain K12 (467 aa), FASTA scores: opt: 986, E(): 0,
                     (43.2% identity in 389 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop) and PS01008 DnaA
                     protein signature. BELONGS TO THE DNAA FAMILY. Note that
                     the first base of this gene has been taken as base 1 of
                     the Mycobacterium bovis genomic sequence. Protein product
                     from Mb0001 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0001 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P49991"
                     /db_xref="InterPro:IPR001957"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR010921"
                     /db_xref="InterPro:IPR013159"
                     /db_xref="InterPro:IPR013317"
                     /db_xref="InterPro:IPR018312"
                     /db_xref="InterPro:IPR020591"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/Swiss-Prot:P49991"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTDDPGSGFT TVWNAVVSEL NGDPKVDDGP SSDANLSAPL TPQQRAWLNL VQPLTIVEGF
       61 ALLSVPSSFV QNEIERHLRA PITDALSRRL GHQIQLGVRI APPATDEADD TTVPPSENPA
      121 TTSPDTTTDN DEIDDSAAAR GDNQHSWPSY FTERPRNTDS ATAGVTSLNR RYTFDTFVIG
      181 ASNRFAHAAA LAIAEAPARA YNPLFIWGES GLGKTHLLHA AGNYAQRLFP GMRVKYVSTE
      241 EFTNDFINSL RDDRKVAFKR SYRDVDVLLV DDIQFIEGKE GIQEEFFHTF NTLHNANKQI
      301 VISSDRPPKQ LATLEDRLRT RFEWGLITDV QPPELETRIA ILRKKAQMER LAIPDDVLEL
      361 IASSIERNIR ELEGALIRVT AFASLNKTPI DKALAEIVLR DLIADANTMQ ISAATIMAAT
      421 AEYFDTTVEE LRGPGKTRAL AQSRQIAMYL CRELTDLSLP KIGQAFGRDH TTVMYAQRKI
      481 LSEMAERREV FDHVKELTTR IRQRSKR
//