LOCUS DAA09124.1 597 aa PRT PLN 23-JAN-2024
DEFINITION Saccharomyces cerevisiae S288C DNA-binding transcription
repressor IXR1 protein.
ACCESSION BK006944-183
PROTEIN_ID DAA09124.1
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 666816)
AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
Bossier,P. et al.
TITLE Complete DNA sequence of yeast chromosome XI
JOURNAL Nature 369 (6479), 371-378 (1994)
PUBMED 8196765
REFERENCE 2 (bases 1 to 666816)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 666816)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
Z28327.1, Z28328.1, Z28329.1 and Z28330.1
On Apr 18, 2011 this sequence version replaced BK006944.1.
Chromosome XI sequence was verified by resequencing. The sequence
was mapped to the previous GenBank records except for a 500 bp
region. That region was determined by sequencing a descendant of
the S288C strain, AB972, and is present in GenBank as JF740677.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Qualifiers
source /organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XI"
protein /gene="IXR1"
/locus_tag="YKL032C"
/gene_synonym="ORD1"
/experiment="EXISTENCE:direct assay:GO:0000785 chromatin
[PMID:19807692]"
/experiment="EXISTENCE:direct assay:GO:0001046 core
promoter sequence-specific DNA binding [PMID:29449612]"
/experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
binding [PMID:8634251]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding
[PMID:11115121|PMID:19807692]"
/experiment="EXISTENCE:genetic interaction:GO:0071456
cellular response to hypoxia [PMID:19807692]"
/experiment="EXISTENCE:genetic interaction:GO:2000819
regulation of nucleotide-excision repair [PMID:8538651]"
/experiment="EXISTENCE:mutant phenotype:GO:0000122
negative regulation of transcription by RNA polymerase II
[PMID:11115121]"
/experiment="EXISTENCE:mutant phenotype:GO:0071456
cellular response to hypoxia [PMID:19807692]"
/experiment="EXISTENCE:mutant phenotype:GO:0090069
regulation of ribosome biogenesis [PMID:29449612]"
/note="Transcriptional repressor that regulates hypoxic
genes during normoxia; involved in the aerobic repression
of genes such as COX5b, TIR1, and HEM13; binds DNA
intrastrand cross-links formed by cisplatin; HMG (high
mobility group box) domain containing protein which binds
and bends cisplatin-modified DNA, blocking excision
repair; IXR1 has a paralog, ABF2, that arose from the
whole genome duplication"
/db_xref="SGD:S000001515"
BEGIN
1 MNTGISPKQD DASNSNLLNI GQDHSLQYQG LEHNDSQYRD ASHQTPHQYL NQFQAQPQQQ
61 QQQQQQQQQQ QQQAPYQGHF QQSPQQQQQN VYYPLPPQSL TQPTSQSQQQ QQQQQQQQYA
121 NSNSNSNNNV NVNALPQDFG YMQQTGSGQN YPTINQQQFS EFYNSFLSHL TQKQTNPSVT
181 GTGASSNNNS NNNNVSSGNN STSSNPAQLA ASQLNPATAA AAAANNAAGP ASYLSQLPQV
241 QRYYPNNMNA LSSLLDPSSA GNAAGNANTA THPGLLPPNL QPQLTHHQQQ MQQQLQLQQQ
301 QQLQQQQQLQ QQHQLQQQQQ LQQQHHHLQQ QQQQQQHPVV KKLSSTQSRI ERRKQLKKQG
361 PKRPSSAYFL FSMSIRNELL QQFPEAKVPE LSKLASARWK ELTDDQKKPF YEEFRTNWEK
421 YRVVRDAYEK TLPPKRPSGP FIQFTQEIRP TVVKENPDKG LIEITKIIGE RWRELDPAKK
481 AEYTETYKKR LKEWESCYPD ENDPNGNPTG HSHKAMNMNL NMDTKIMENQ DSIEHITANA
541 IDSVTGSNSN STNPNTPVSP PISLQQQPLQ QQQQQQQQQQ HMLLADPTTN GSIIKNE
//