LOCUS DAA09103.1 738 aa PRT PLN 23-JAN-2024
DEFINITION Saccharomyces cerevisiae S288C DNA damage-responsive RNA
polymerase-degradation factor DEF1 protein.
ACCESSION BK006944-161
PROTEIN_ID DAA09103.1
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 666816)
AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
Bossier,P. et al.
TITLE Complete DNA sequence of yeast chromosome XI
JOURNAL Nature 369 (6479), 371-378 (1994)
PUBMED 8196765
REFERENCE 2 (bases 1 to 666816)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 666816)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
Z28327.1, Z28328.1, Z28329.1 and Z28330.1
On Apr 18, 2011 this sequence version replaced BK006944.1.
Chromosome XI sequence was verified by resequencing. The sequence
was mapped to the previous GenBank records except for a 500 bp
region. That region was determined by sequencing a descendant of
the S288C strain, AB972, and is present in GenBank as JF740677.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Qualifiers
source /organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XI"
protein /gene="DEF1"
/locus_tag="YKL054C"
/gene_synonym="VID31"
/experiment="EXISTENCE:direct assay:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:11859374]"
/experiment="EXISTENCE:direct assay:GO:0062058
transcription factor TFIIH holo complex binding
[PMID:29180430]"
/experiment="EXISTENCE:genetic interaction:GO:0006283
transcription-coupled nucleotide-excision repair
[PMID:17537816]"
/experiment="EXISTENCE:mutant phenotype:GO:0000723
telomere maintenance [PMID:15863512]"
/experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus
[PMID:11859374]"
/experiment="EXISTENCE:mutant phenotype:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:11859374]"
/experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA
damage response [PMID:11859374]"
/experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
ubiquitination [PMID:24465179]"
/experiment="EXISTENCE:mutant phenotype:GO:0060261
positive regulation of transcription initiation by RNA
polymerase II [PMID:29180430]"
/note="RNAPII degradation factor; forms a complex with
Rad26p in chromatin, enables ubiquitination and
proteolysis of RNAPII present in an elongation complex;
interacts with general transcription factor TFIIH; mutant
is deficient in Zip1p loading onto chromosomes during
meiosis; null mutant is prone to self-diploidization; null
mutation can be functionally complemented by human UBAP2
and UBAP2"
/db_xref="SGD:S000001537"
BEGIN
1 MSTQFRKSNH NSHSSKKLNP ALKSKIDTLT ELFPDWTSDD LIDIVQEYDD LETIIDKITS
61 GAVTRWDEVK KPAKKEKYEK KEQQHSYVPQ QHLPNPEDDI TYKSSNNSNS FTSTKHNSSN
121 NYTQARNKKK VQTPRAHTTG KHVNLDKGKH VPSKPVSNTT SWAAAVSVDT KHDVPQDSND
181 NNNEELEAQG QQAQEKNQEK EQEEQQQQEG HNNKEEHKQI EQPSLSSKKT TSRTSASQPK
241 KMSWAAIATP KPKAVKKTES PLENVAELKK EISDIKKDDQ KSEASEEKVN EQETSAQEQE
301 EETAEPSEEN EDRVPEVDGE EVQEEAEKKE QVKEEEQTAE ELEQEQDNVA APEEEVTVVE
361 EKVEISAVIS EPPEDQANTV PQPQQQSQQP QQPQQPQQPQ QPQQPQQQQQ PQQPQQPQQQ
421 LQQQQQQQQQ PVQAQAQAQE EQLSQNYYTQ QQQQQYAQQQ HQLQQQYLSQ QQQYAQQQQQ
481 HPQPQSQQPQ SQQSPQSQKQ GNNVAAQQYY MYQNQFPGYS YPGMFDSQGY AYGQQYQQLA
541 QNNAQTSGNA NQYNFQQGYG QAGANTAAAN LTSAAAAAAA SPATAHAQPQ QQQPYGGSFM
601 PYYAHFYQQS FPYGQPQYGV AGQYPYQLPK NNYNYYQTQN GQEQQSPNQG VAQHSEDSQQ
661 KQSQQQQQQQ PQGQPQPEVQ MQNGQPVNPQ QQMQFQQYYQ FQQQQQQAAA AAAAAAQQGV
721 PYGYNGYDYN SKNSRGFY
//