LOCUS       DAA09089.1               959 aa    PRT              PLN 23-JAN-2024
DEFINITION  Saccharomyces cerevisiae S288C FG-nucleoporin NUP100 protein.
ACCESSION   BK006944-147
PROTEIN_ID  DAA09089.1
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 666816)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   2  (bases 1 to 666816)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 666816)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   4  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
REFERENCE   5  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   6  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
COMMENT     THIRD PARTY DATABASE: This TPA record uses data from
            DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
            Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
            Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
            Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
            Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
            Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
            Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
            Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
            Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
            Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
            Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
            Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
            Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
            Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
            Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
            Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
            Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
            Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
            Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
            Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
            Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
            Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
            Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
            Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
            Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
            Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
            Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
            Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
            Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
            Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
            Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
            Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
            Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
            Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
            Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
            Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
            Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
            Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
            Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
            Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
            Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
            Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
            Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
            Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
            Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
            Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
            Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
            Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
            Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
            Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
            Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
            Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
            Z28327.1, Z28328.1, Z28329.1 and Z28330.1
            
            On Apr 18, 2011 this sequence version replaced BK006944.1.
            Chromosome XI sequence was verified by resequencing.  The sequence
            was mapped to the previous GenBank records except for a 500 bp
            region.  That region was determined by sequencing a descendant of
            the S288C strain, AB972, and is present in GenBank as JF740677.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="genomic DNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     protein         /gene="NUP100"
                     /locus_tag="YKL068W"
                     /gene_synonym="NSP100"
                     /experiment="EXISTENCE:direct assay:GO:0005643 nuclear
                     pore [PMID:10684247|PMID:8195299]"
                     /experiment="EXISTENCE:direct assay:GO:0017056 structural
                     constituent of nuclear pore [PMID:19098896]"
                     /experiment="EXISTENCE:direct assay:GO:0044613 nuclear
                     pore central transport channel [PMID:18046406]"
                     /experiment="EXISTENCE:genetic interaction:GO:0006606
                     protein import into nucleus [PMID:20647373]"
                     /experiment="EXISTENCE:genetic interaction:GO:0006607
                     NLS-bearing protein import into nucleus [PMID:15039779]"
                     /experiment="EXISTENCE:genetic interaction:GO:0017056
                     structural constituent of nuclear pore [PMID:20647373]"
                     /experiment="EXISTENCE:genetic interaction:GO:0036228
                     protein localization to nuclear inner membrane
                     [PMID:21659568]"
                     /experiment="EXISTENCE:genetic interaction:GO:0045893
                     positive regulation of DNA-templated transcription
                     [PMID:15817685]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000973
                     post-transcriptional tethering of RNA polymerase II gene
                     DNA at nuclear periphery [PMID:20932479]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0017056
                     structural constituent of nuclear pore [PMID:17418788]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA
                     export from nucleus in response to heat stress
                     [PMID:18258809]"
                     /experiment="EXISTENCE:mutant phenotype:GO:2000238
                     regulation of tRNA export from nucleus [PMID:27932586]"
                     /experiment="EXISTENCE:physical interaction:GO:0006406
                     mRNA export from nucleus [PMID:11104765]"
                     /experiment="EXISTENCE:physical interaction:GO:0017056
                     structural constituent of nuclear pore
                     [PMID:19098896|PMID:12917401|PMID:17803941|PMID:17418788]"
                     /note="FG-nucleoporin component of central core of the
                     nuclear pore complex; contributes directly to
                     nucleocytoplasmic transport and maintenance of the nuclear
                     pore complex (NPC) permeability barrier and is involved in
                     gene tethering at the nuclear periphery; NUP100 has a
                     paralog, NUP116, that arose from the whole genome
                     duplication"
                     /db_xref="SGD:S000001551"
BEGIN
        1 MFGNNRPMFG GSNLSFGSNT SSFGGQQSQQ PNSLFGNSNN NNNSTSNNAQ SGFGGFTSAA
       61 GSNSNSLFGN NNTQNNGAFG QSMGATQNSP FGSLNSSNAS NGNTFGGSSS MGSFGGNTNN
      121 AFNNNSNSTN SPFGFNKPNT GGTLFGSQNN NSAGTSSLFG GQSTSTTGTF GNTGSSFGTG
      181 LNGNGSNIFG AGNNSQSNTT GSLFGNQQSS AFGTNNQQGS LFGQQSQNTN NAFGNQNQLG
      241 GSSFGSKPVG SGSLFGQSNN TLGNTTNNRN GLFGQMNSSN QGSSNSGLFG QNSMNSSTQG
      301 VFGQNNNQMQ INGNNNNSLF GKANTFSNSA SGGLFGQNNQ QQGSGLFGQN SQTSGSSGLF
      361 GQNNQKQPNT FTQSNTGIGL FGQNNNQQQQ STGLFGAKPA GTTGSLFGGN SSTQPNSLFG
      421 TTNVPTSNTQ SQQGNSLFGA TKLTNMPFGG NPTANQSGSG NSLFGTKPAS TTGSLFGNNT
      481 ASTTVPSTNG LFGNNANNST STTNTGLFGA KPDSQSKPAL GGGLFGNSNS NSSTIGQNKP
      541 VFGGTTQNTG LFGATGTNSS AVGSTGKLFG QNNNTLNVGT QNVPPVNNTT QNALLGTTAV
      601 PSLQQAPVTN EQLFSKISIP NSITNPVKAT TSKVNADMKR NSSLTSAYRL APKPLFAPSS
      661 NGDAKFQKWG KTLERSDRGS STSNSITDPE SSYLNSNDLL FDPDRRYLKH LVIKNNKNLN
      721 VINHNDDEAS KVKLVTFTTE SASKDDQASS SIAASKLTEK AHSPQTDLKD DHDESTPDPQ
      781 SKSPNGSTSI PMIENEKISS KVPGLLSNDV TFFKNNYYIS PSIETLGNKS LIELRKINNL
      841 VIGHRNYGKV EFLEPVDLLN TPLDTLCGDL VTFGPKSCSI YENCSIKPEK GEGINVRCRV
      901 TLYSCFPIDK ETRKPIKNIT HPLLKRSIAK LKENPVYKFE SYDPVTGTYS YTIDHPVLT
//