LOCUS DAA09057.1 587 aa PRT PLN 23-JAN-2024 DEFINITION Saccharomyces cerevisiae S288C aspartic endopeptidase protein. ACCESSION BK006944-114 PROTEIN_ID DAA09057.1 SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (bases 1 to 666816) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 2 (bases 1 to 666816) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (bases 1 to 666816) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 4 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REFERENCE 5 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1, Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1, Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1, Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1, Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1, Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1, Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1, Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1, Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1, Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1, Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1, Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1, Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1, Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1, Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1, Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1, Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1, Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1, Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1, Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1, Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1, Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1, Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1, Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1, Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1, Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1, Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1, Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1, Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1, Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1, Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1, Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1, Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1, Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1, Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1, Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1, Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1, Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1, Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1, Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1, Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1, Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1, Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1, Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1, Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1, Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1, Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1, Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1, Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1, Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1, Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1, Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1, Z28327.1, Z28328.1, Z28329.1 and Z28330.1 On Apr 18, 2011 this sequence version replaced BK006944.1. Chromosome XI sequence was verified by resequencing. The sequence was mapped to the previous GenBank records except for a 500 bp region. That region was determined by sequencing a descendant of the S288C strain, AB972, and is present in GenBank as JF740677. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## FEATURES Qualifiers source /organism="Saccharomyces cerevisiae S288C" /mol_type="genomic DNA" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" protein /gene="YPF1" /locus_tag="YKL100C" /experiment="EXISTENCE:direct assay:GO:1990578 perinuclear endoplasmic reticulum membrane [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0042500 aspartic endopeptidase activity, intramembrane cleaving [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:25454947]" /note="Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)" /db_xref="SGD:S000001583" BEGIN 1 MDKYLNSFVD HLSEWSSRAF RNNSSSANQS ASNKELEQVF EQINAIVENH NNKLTTAFDK 61 ISYRVAHKIT HLVESHSLVF NYATLVLIAS ALVVIGSFTS ISSIPFTALP PTREHSLFDP 121 TDFDVDHDCH VIYRENDEDK KKKKKSKRFF DMMDEKHAII LPLTSGCTLL ALYFVIKKLH 181 LNWLKYVVKI LNFNITLLNI PAGTFVYSYF LNSLFRNLSH LASWNPLVVL PRYRVTIADD 241 NEDLNKIGGF VTNLNYKDGL TNSVVHKKTL DEIEKDHWMK HFYRRELVEP KDIKSKRQIS 301 NMYLNSALIV SFVLSIVSTV YFYLSPNDWL ISNAVSMNMA IWSIAQLKLK NLKSGALILI 361 ALFFYDICFV FGTDVMVTVA TNLDIPVKLS LPVKFNTAQN NFNFSILGLG DIALPGMFIA 421 MCYKYDIWKW HLDHDDTEFH FLNWSYVGKY FITAMVSYVA SLVSAMVSLS IFNTAQPALL 481 YIVPSLLIST ILVACWNKDF KQFWNFQYDT IEVDKSLKKA IEKKENSITY STFILSEYYN 541 DADKYALLGD DVNENFDDDE EFVQEEDLSD SSEEELSEED LLDDESS //