LOCUS DAA09056.2 1518 aa PRT PLN 23-JAN-2024
DEFINITION Saccharomyces cerevisiae S288C protein kinase HSL1 protein.
ACCESSION BK006944-113
PROTEIN_ID DAA09056.2
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 666816)
AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
Bossier,P. et al.
TITLE Complete DNA sequence of yeast chromosome XI
JOURNAL Nature 369 (6479), 371-378 (1994)
PUBMED 8196765
REFERENCE 2 (bases 1 to 666816)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 666816)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
Z28327.1, Z28328.1, Z28329.1 and Z28330.1
On Apr 18, 2011 this sequence version replaced BK006944.1.
Chromosome XI sequence was verified by resequencing. The sequence
was mapped to the previous GenBank records except for a 500 bp
region. That region was determined by sequencing a descendant of
the S288C strain, AB972, and is present in GenBank as JF740677.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Qualifiers
source /organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XI"
protein /gene="HSL1"
/locus_tag="YKL101W"
/gene_synonym="ELM2"
/gene_synonym="NIK1"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0000144 cellular
bud neck septin ring [PMID:27053666|PMID:9925642]"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:9925642|PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity [PMID:11408575]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:10805747|PMID:15282802]"
/experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M
transition of mitotic cell cycle [PMID:10490630]"
/experiment="EXISTENCE:mutant phenotype:GO:0004674 protein
serine/threonine kinase activity [PMID:11408575]"
/experiment="EXISTENCE:mutant phenotype:GO:0030163 protein
catabolic process [PMID:23042131]"
/experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic
morphogenesis checkpoint signaling [PMID:9925642]"
/experiment="EXISTENCE:mutant phenotype:GO:0051726
regulation of cell cycle [PMID:8647431]"
/experiment="EXISTENCE:mutant phenotype:GO:1902935 protein
localization to septin ring [PMID:27053666]"
/experiment="EXISTENCE:physical interaction:GO:0000144
cellular bud neck septin ring [PMID:9925642]"
/note="Nim1p-related protein kinase; septin-binding kinase
that localizes to the bud neck septin ring and regulates
the morphogenesis checkpoint; phosphorylates Hsl7p and
cooperates with Elm1p to recruit Hsl7p to the mother-bud
neck, as a prerequisite for the subsequent recruitment,
phosphorylation, and degradation of Swe1p;
autophosphorylation enhances interactions with Hsl7p"
/db_xref="SGD:S000001584"
BEGIN
1 MTGHVSKTSH VPKGRPSSLA KKAAKRAMAK VNSNPKRASG HLERVVQSVN DATKRLSQPD
61 STVSVATKSS KRKSRDTVGP WKLGKTLGKG SSGRVRLAKN METGQLAAIK IVPKKKAFVH
121 CSNNGTVPNS YSSSMVTSNV SSPSIASREH SNHSQTNPYG IEREIVIMKL ISHTNVMALF
181 EVWENKSELY LVLEYVDGGE LFDYLVSKGK LPEREAIHYF KQIVEGVSYC HSFNICHRDL
241 KPENLLLDKK NRRIKIADFG MAALELPNKL LKTSCGSPHY ASPEIVMGRP YHGGPSDVWS
301 CGIVLFALLT GHLPFNDDNI KKLLLKVQSG KYQMPSNLSS EARDLISKIL VIDPEKRITT
361 QEILKHPLIK KYDDLPVNKV LRKMRKDNMA RGKSNSDLHL LNNVSPSIVT LHSKGEIDES
421 ILRSLQILWH GVSRELITAK LLQKPMSEEK LFYSLLLQYK QRHSISLSSS SENKKSATES
481 SVNEPRIEYA SKTANNTGLR SENNDVKTLH SLEIHSEDTS TVNQNNAITG VNTEINAPVL
541 AQKSQFSINT LSQPESDKAE AEAVTLPPAI PIFNASSSRI FRNSYTSISS RSRRSLRLSN
601 SRLSLSASTS RETVHDNEMP LPQLPKSPSR YSLSRRAIHA SPSTKSIHKS LSRKNIAATV
661 AARRTLQNSA SKRSLYSLQS ISKRSLNLND LLVFDDPLPS KKPASENVNK SEPHSLESDS
721 DFEILCDQIL FGNALDRILE EEEDNEKERD TQRQRQNDTK SSADTFTISG VSTNKENEGP
781 EYPTKIEKNQ FNMSYKPSEN MSGLSSFPIF EKENTLSSSY LEEQKPKRAA LSDITNSFNK
841 MNKQEGMRIE KKIQREQLQK KNDRPSPLKP IQHQELRVNS LPNDQGKPSL SLDPRRNISQ
901 PVNSKVESLL QGLKFKKEPA SHWTHERGSL FMSEHVEDEK PVKASDVSIE SSYVPLTTVA
961 TSSRDPSVLA ESSTIQKPML SLPSSFLNTS MTFKNLSQIL ADDGDDKHLS VPQNQSRSVA
1021 MSHPLRKQSA KISLTPRSNL NANLSVKRNQ GSPGSYLSND LDGISDMTFA MEIPTNTFTA
1081 QAIQLMNNDT DNNKINTSPK ASSFTKEKVI KSAAYISKEK EPDNSDTNYI PDYTIPNTYD
1141 EKAINIFEDA PSDEGSLNTS SSESDSRASV HRKAVSIDTM ATTNVLTPAT NVRVSLYWNN
1201 NSSGIPRETT EEILSKLRLS PENPSNTHMQ KRFSSTRGSR DSNALGISQS LQSMFKDLEE
1261 DQDGHTSQAD ILESSMSYSK RRPSEESVNP KQRVTMLFDE EEEESKKVGG GKIKEEHTKL
1321 DNKISEESSQ LVLPVVEKKE NANNTENNYS KIPKPSTIKV TKDTAMESNT QTHTKKPILK
1381 SVQNVEVEEA PSSDKKNWFV KLFQNFSSHN NATKASKNHV TNISFDDAHM LTLNEFNKNS
1441 IDYQLKNLDH KFGRKVVEYD CKFVKGNFKF KIKITSTPNA STVITVKKRS KHSNTSSNKA
1501 FEKFNDDVER VIRNAGRS
//