LOCUS DAA09055.1 514 aa PRT PLN 23-JAN-2024 DEFINITION Saccharomyces cerevisiae S288C metalloaminopeptidase APE1 protein. ACCESSION BK006944-111 PROTEIN_ID DAA09055.1 SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (bases 1 to 666816) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 2 (bases 1 to 666816) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (bases 1 to 666816) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 4 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REFERENCE 5 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (bases 1 to 666816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1, Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1, Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1, Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1, Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1, Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1, Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1, Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1, Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1, Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1, Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1, Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1, Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1, Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1, Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1, Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1, Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1, Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1, Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1, Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1, Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1, Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1, Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1, Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1, Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1, Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1, Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1, Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1, Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1, Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1, Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1, Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1, Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1, Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1, Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1, Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1, Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1, Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1, Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1, Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1, Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1, Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1, Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1, Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1, Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1, Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1, Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1, Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1, Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1, Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1, Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1, Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1, Z28327.1, Z28328.1, Z28329.1 and Z28330.1 On Apr 18, 2011 this sequence version replaced BK006944.1. Chromosome XI sequence was verified by resequencing. The sequence was mapped to the previous GenBank records except for a 500 bp region. That region was determined by sequencing a descendant of the S288C strain, AB972, and is present in GenBank as JF740677. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## FEATURES Qualifiers source /organism="Saccharomyces cerevisiae S288C" /mol_type="genomic DNA" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" protein /gene="APE1" /locus_tag="YKL103C" /gene_synonym="API" /gene_synonym="LAP4" /gene_synonym="YSC1" /EC_number="3.4.11.22" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:1400574]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:9151668|PMID:9412464|PMID:20659891]" /experiment="EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:3882418]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole transport by the Cvt pathway [PMID:18725539]" /note="Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to peptidase family M18; often used as marker in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway" /db_xref="SGD:S000001586" BEGIN 1 MEEQREILEQ LKKTLQMLTV EPSKNNQIAN EEKEKKENEN SWCILEHNYE DIAQEFIDFI 61 YKNPTTYHVV SFFAELLDKH NFKYLSEKSN WQDSIGEDGG KFYTIRNGTN LSAFILGKNW 121 RAEKGVGVIG SHVDALTVKL KPVSFKDTAE GYGRIAVAPY GGTLNELWLD RDLGIGGRLL 181 YKKKGTNEIK SALVDSTPLP VCRIPSLAPH FGKPAEGPFD KEDQTIPVIG FPTPDEEGNE 241 PPTDDEKKSP LFGKHCIHLL RYVAKLAGVE VSELIQMDLD LFDVQKGTIG GIGKHFLFAP 301 RLDDRLCSFA AMIALICYAK DVNTEESDLF STVTLYDNEE IGSLTRQGAK GGLLESVVER 361 SSSAFTKKPV DLHTVWANSI ILSADVNHLY NPNFPEVYLK NHFPVPNVGI TLSLDPNGHM 421 ATDVVGTALV EELARRNGDK VQYFQIKNNS RSGGTIGPSL ASQTGARTID LGIAQLSMHS 481 IRAATGSKDV GLGVKFFNGF FKHWRSVYDE FGEL //