LOCUS       DAA09041.1               215 aa    PRT              PLN 23-JAN-2024
DEFINITION  Saccharomyces cerevisiae S288C Vph2p protein.
ACCESSION   BK006944-96
PROTEIN_ID  DAA09041.1
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 666816)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   2  (bases 1 to 666816)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 666816)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   4  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
REFERENCE   5  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   6  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
COMMENT     THIRD PARTY DATABASE: This TPA record uses data from
            DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
            Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
            Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
            Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
            Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
            Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
            Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
            Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
            Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
            Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
            Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
            Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
            Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
            Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
            Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
            Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
            Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
            Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
            Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
            Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
            Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
            Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
            Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
            Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
            Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
            Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
            Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
            Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
            Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
            Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
            Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
            Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
            Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
            Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
            Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
            Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
            Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
            Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
            Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
            Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
            Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
            Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
            Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
            Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
            Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
            Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
            Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
            Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
            Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
            Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
            Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
            Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
            Z28327.1, Z28328.1, Z28329.1 and Z28330.1
            
            On Apr 18, 2011 this sequence version replaced BK006944.1.
            Chromosome XI sequence was verified by resequencing.  The sequence
            was mapped to the previous GenBank records except for a 500 bp
            region.  That region was determined by sequencing a descendant of
            the S288C strain, AB972, and is present in GenBank as JF740677.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="genomic DNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     protein         /gene="VPH2"
                     /locus_tag="YKL119C"
                     /gene_synonym="CLS10"
                     /gene_synonym="VMA12"
                     /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
                     reticulum [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
                     reticulum membrane [PMID:9325326]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007035
                     vacuolar acidification [PMID:1628805]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0070072
                     vacuolar proton-transporting V-type ATPase complex
                     assembly [PMID:9325326]"
                     /experiment="EXISTENCE:physical interaction:GO:1990871
                     Vma12-Vma22 assembly complex [PMID:9660861]"
                     /note="Integral membrane protein required for V-ATPase
                     function; not an actual component of the vacuolar
                     H+-ATPase (V-ATPase) complex; functions in the assembly of
                     the V-ATPase; localized to the endoplasmic reticulum (ER);
                     involved in methionine restriction extension of
                     chronological lifespan in an autophagy-dependent manner"
                     /db_xref="SGD:S000001602"
BEGIN
        1 MFEIKLNDRI TEFLRKFKNS AKSNEGIDED IDLFLKRHAI PMQSLLFYVK EYRKDSDLQC
       61 SIKELLKPLE FEFKPKAVRG LHYSEDFKKK LEFLKYQEQE LEYQSMVKRS KSVFSLQEDD
      121 ELTPSQINKQ IKEQVTTVFN VLVSVISVVV AIWYWTGSST NFPVHVRLLL CLFFGILVLV
      181 ADVVVYNSYL KKLEEAKVKE KTKVEKKKVL SKITL
//