LOCUS DAA09007.2 952 aa PRT PLN 23-JAN-2024
DEFINITION Saccharomyces cerevisiae S288C metallo-aminopeptidase protein.
ACCESSION BK006944-62
PROTEIN_ID DAA09007.2
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 666816)
AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
Bossier,P. et al.
TITLE Complete DNA sequence of yeast chromosome XI
JOURNAL Nature 369 (6479), 371-378 (1994)
PUBMED 8196765
REFERENCE 2 (bases 1 to 666816)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 666816)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
Z28327.1, Z28328.1, Z28329.1 and Z28330.1
On Apr 18, 2011 this sequence version replaced BK006944.1.
Chromosome XI sequence was verified by resequencing. The sequence
was mapped to the previous GenBank records except for a 500 bp
region. That region was determined by sequencing a descendant of
the S288C strain, AB972, and is present in GenBank as JF740677.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Qualifiers
source /organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XI"
protein /gene="APE2"
/locus_tag="YKL157W"
/gene_synonym="LAP1"
/gene_synonym="YKL158W"
/experiment="EXISTENCE:direct assay:GO:0005576
extracellular region [PMID:383482]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0030287 cell
wall-bounded periplasmic space [PMID:383482]"
/experiment="EXISTENCE:direct assay:GO:0043171 peptide
catabolic process [PMID:6352682]"
/experiment="EXISTENCE:direct assay:GO:0070006
metalloaminopeptidase activity [PMID:6352682]"
/experiment="EXISTENCE:mutant phenotype:GO:0043171 peptide
catabolic process [PMID:3286257]"
/note="Aminopeptidase yscII; may have role in obtaining
leucine from dipeptide substrates; targeted to vacuole via
Vps10p-dependent endosomal vacuolar protein sorting
pathway; APE2 has a paralog, AAP1, that arose from the
whole genome duplication"
/db_xref="SGD:S000001640"
intron_pos 94:2 (1/1)
BEGIN
1 MPIVRWLLLK SAVRGSSLIG KAHPCLRSIA AHPRYLSNVY SPPAGVSRSL RINVMWKQSK
61 LTPPRFVKIM NRRPLFTETS HACAKCQKTS QLLNKTPNRE ILPDNVVPLH YDLTVEPDFK
121 TFKFEGSVKI ELKINNPAID TVTLNTVDTD IHSAKIGDVT SSEIISEEEQ QVTTFAFPKG
181 TMSSFKGNAF LDIKFTGILN DNMAGFYRAK YEDKLTGETK YMATTQMEPT DARRAFPCFD
241 EPNLKASFAI TLVSDPSLTH LSNMDVKNEY VKDGKKVTLF NTTPKMSTYL VAFIVAELKY
301 VESKNFRIPV RVYATPGNEK HGQFAADLTA KTLAFFEKTF GIQYPLPKMD NVAVHEFSAG
361 AMENWGLVTY RVVDLLLDKD NSTLDRIQRV AEVVQHELAH QWFGNLVTMD WWEGLWLNEG
421 FATWMSWYSC NEFQPEWKVW EQYVTDTLQH ALSLDSLRSS HPIEVPVKKA DEINQIFDAI
481 SYSKGASLLR MISKWLGEET FIKGVSQYLN KFKYGNAKTE DLWDALADAS GKDVRSVMNI
541 WTKKVGFPVI SVSEDGNGKI TFRQNRYLST ADVKPDEDKT IYPVFLALKT KNGVDSSVVL
601 SERSKTIELE DPTFFKVNSE QSGIYITSYT DERWAKLGQQ ADLLSVEDRV GLVADVKTLS
661 ASGYTSTTNF LNLVSKWNNE KSFVVWDQII NSISSMKSTW LFEPKETQDA LDNFTKQLIS
721 GMTHHLGWEF KSSDSFSTQR LKVTMFGAAC AARDADVEKA ALKMFTDYCS GNKEAIPALI
781 KPIVFNTVAR VGGAENYEKV YKIYLDPISN DEKLAALRSL GRFKEPKLLE RTLGYLFDGT
841 VLNQDIYIPM QGMRAHQEGV EALWNWVKKN WDELVKRLPP GLSMLGSVVT LGTSGFTSMQ
901 KIDEIKKFFA TKSTKGFDQS LAQSLDTITS KAQWVNRDRD VVNKYLKENG YY
//