LOCUS       DAA08985.1              2051 aa    PRT              PLN 23-JAN-2024
DEFINITION  Saccharomyces cerevisiae S288C tetrafunctional fatty acid
            synthase subunit FAS1 protein.
ACCESSION   BK006944-40
PROTEIN_ID  DAA08985.1
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 666816)
  AUTHORS   Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
            Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
            Bossier,P. et al.
  TITLE     Complete DNA sequence of yeast chromosome XI
  JOURNAL   Nature 369 (6479), 371-378 (1994)
   PUBMED   8196765
REFERENCE   2  (bases 1 to 666816)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 666816)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   4  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
REFERENCE   5  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   6  (bases 1 to 666816)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
COMMENT     THIRD PARTY DATABASE: This TPA record uses data from
            DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
            Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
            Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
            Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
            Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
            Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
            Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
            Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
            Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
            Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
            Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
            Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
            Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
            Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
            Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
            Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
            Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
            Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
            Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
            Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
            Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
            Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
            Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
            Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
            Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
            Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
            Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
            Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
            Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
            Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
            Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
            Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
            Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
            Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
            Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
            Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
            Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
            Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
            Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
            Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
            Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
            Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
            Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
            Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
            Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
            Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
            Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
            Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
            Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
            Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
            Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
            Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
            Z28327.1, Z28328.1, Z28329.1 and Z28330.1
            
            On Apr 18, 2011 this sequence version replaced BK006944.1.
            Chromosome XI sequence was verified by resequencing.  The sequence
            was mapped to the previous GenBank records except for a 500 bp
            region.  That region was determined by sequencing a descendant of
            the S288C strain, AB972, and is present in GenBank as JF740677.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="genomic DNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XI"
     protein         /gene="FAS1"
                     /locus_tag="YKL182W"
                     /EC_number="1.3.1.9"
                     /EC_number="2.3.1.38"
                     /EC_number="2.3.1.39"
                     /EC_number="2.3.1.86"
                     /EC_number="3.1.2.14"
                     /EC_number="4.2.1.59"
                     /experiment="EXISTENCE:direct assay:GO:0004313
                     [acyl-carrier-protein] S-acetyltransferase activity
                     [PMID:374077]"
                     /experiment="EXISTENCE:direct assay:GO:0004314
                     [acyl-carrier-protein] S-malonyltransferase activity
                     [PMID:365179|PMID:374077]"
                     /experiment="EXISTENCE:direct assay:GO:0004319
                     enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)
                     activity [PMID:374077]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:14562095]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:14576278|PMID:16823961]"
                     /experiment="EXISTENCE:direct assay:GO:0005811 lipid
                     droplet [PMID:17803462]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:6025308]"
                     /experiment="EXISTENCE:direct assay:GO:0005835 fatty acid
                     synthase complex [PMID:65153]"
                     /experiment="EXISTENCE:direct assay:GO:0016409
                     palmitoyltransferase activity [PMID:365179]"
                     /experiment="EXISTENCE:direct assay:GO:0019171
                     (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     activity [PMID:374077]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004312 fatty
                     acid synthase activity [PMID:1100391|PMID:65153]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004313
                     [acyl-carrier-protein] S-acetyltransferase activity
                     [PMID:1100391]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004314
                     [acyl-carrier-protein] S-malonyltransferase activity
                     [PMID:1100391]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004319
                     enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)
                     activity [PMID:1100391]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016409
                     palmitoyltransferase activity [PMID:1100391]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0019171
                     (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase
                     activity [PMID:1100391]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0042759
                     long-chain fatty acid biosynthetic process
                     [PMID:1735446|PMID:4127627]"
                     /note="Beta subunit of fatty acid synthetase; complex
                     catalyzes the synthesis of long-chain saturated fatty
                     acids; contains acetyltransacylase, dehydratase, enoyl
                     reductase, malonyl transacylase, and palmitoyl
                     transacylase activities; specific target of the
                     broad-spectrum antifungal NPD6433"
                     /db_xref="SGD:S000001665"
BEGIN
        1 MDAYSTRPLT LSHGSLEHVL LVPTASFFIA SQLQEQFNKI LPEPTEGFAA DDEPTTPAEL
       61 VGKFLGYVSS LVEPSKVGQF DQVLNLCLTE FENCYLEGND IHALAAKLLQ ENDTTLVKTK
      121 ELIKNYITAR IMAKRPFDKK SNSALFRAVG EGNAQLVAIF GGQGNTDDYF EELRDLYQTY
      181 HVLVGDLIKF SAETLSELIR TTLDAEKVFT QGLNILEWLE NPSNTPDKDY LLSIPISCPL
      241 IGVIQLAHYV VTAKLLGFTP GELRSYLKGA TGHSQGLVTA VAIAETDSWE SFFVSVRKAI
      301 TVLFFIGVRC YEAYPNTSLP PSILEDSLEN NEGVPSPMLS ISNLTQEQVQ DYVNKTNSHL
      361 PAGKQVEISL VNGAKNLVVS GPPQSLYGLN LTLRKAKAPS GLDQSRIPFS ERKLKFSNRF
      421 LPVASPFHSH LLVPASDLIN KDLVKNNVSF NAKDIQIPVY DTFDGSDLRV LSGSISERIV
      481 DCIIRLPVKW ETTTQFKATH ILDFGPGGAS GLGVLTHRNK DGTGVRVIVA GTLDINPDDD
      541 YGFKQEIFDV TSNGLKKNPN WLEEYHPKLI KNKSGKIFVE TKFSKLIGRP PLLVPGMTPC
      601 TVSPDFVAAT TNAGYTIELA GGGYFSAAGM TAAIDSVVSQ IEKGSTFGIN LIYVNPFMLQ
      661 WGIPLIKELR SKGYPIQFLT IGAGVPSLEV ASEYIETLGL KYLGLKPGSI DAISQVINIA
      721 KAHPNFPIAL QWTGGRGGGH HSFEDAHTPM LQMYSKIRRH PNIMLIFGSG FGSADDTYPY
      781 LTGEWSTKFD YPPMPFDGFL FGSRVMIAKE VKTSPDAKKC IAACTGVPDD KWEQTYKKPT
      841 GGIVTVRSEM GEPIHKIATR GVMLWKEFDE TIFNLPKNKL VPTLEAKRDY IISRLNADFQ
      901 KPWFATVNGQ ARDLATMTYE EVAKRLVELM FIRSTNSWFD VTWRTFTGDF LRRVEERFTK
      961 SKTLSLIQSY SLLDKPDEAI EKVFNAYPAA REQFLNAQDI DHFLSMCQNP MQKPVPFVPV
     1021 LDRRFEIFFK KDSLWQSEHL EAVVDQDVQR TCILHGPVAA QFTKVIDEPI KSIMDGIHDG
     1081 HIKKLLHQYY GDDESKIPAV EYFGGESPVD VQSQVDSSSV SEDSAVFKAT SSTDEESWFK
     1141 ALAGSEINWR HASFLCSFIT QDKMFVSNPI RKVFKPSQGM VVEISNGNTS SKTVVTLSEP
     1201 VQGELKPTVI LKLLKENIIQ MEMIENRTMD GKPVSLPLLY NFNPDNGFAP ISEVMEDRNQ
     1261 RIKEMYWKLW IDEPFNLDFD PRDVIKGKDF EITAKEVYDF THAVGNNCED FVSRPDRTML
     1321 APMDFAIVVG WRAIIKAIFP NTVDGDLLKL VHLSNGYKMI PGAKPLQVGD VVSTTAVIES
     1381 VVNQPTGKIV DVVGTLSRNG KPVMEVTSSF FYRGNYTDFE NTFQKTVEPV YQMHIKTSKD
     1441 IAVLRSKEWF QLDDEDFDLL NKTLTFETET EVTFKNANIF SSVKCFGPIK VELPTKETVE
     1501 IGIVDYEAGA SHGNPVVDFL KRNGSTLEQK VNLENPIPIA VLDSYTPSTN EPYARVSGDL
     1561 NPIHVSRHFA SYANLPGTIT HGMFSSASVR ALIENWAADS VSSRVRGYTC QFVDMVLPNT
     1621 ALKTSIQHVG MINGRKLIKF ETRNEDDVVV LTGEAEIEQP VTTFVFTGQG SQEQGMGMDL
     1681 YKTSKAAQDV WNRADNHFKD TYGFSILDIV INNPVNLTIH FGGEKGKRIR ENYSAMIFET
     1741 IVDGKLKTEK IFKEINEHST SYTFRSEKGL LSATQFTQPA LTLMEKAAFE DLKSKGLIPA
     1801 DATFAGHSLG EYAALASLAD VMSIESLVEV VFYRGMTMQV AVPRDELGRS NYGMIAINPG
     1861 RVAASFSQEA LQYVVERVGK RTGWLVEIVN YNVENQQYVA AGDLRALDTV TNVLNFIKLQ
     1921 KIDIIELQKS LSLEEVEGHL FEIIDEASKK SAVKPRPLKL ERGFACIPLV GISVPFHSTY
     1981 LMNGVKPFKS FLKKNIIKEN VKVARLAGKY IPNLTAKPFQ VTKEYFQDVY DLTGSEPIKE
     2041 IIDNWEKYEQ S
//