LOCUS DAA08957.1 623 aa PRT PLN 23-JAN-2024
DEFINITION Saccharomyces cerevisiae S288C phosphatidylinositol-3-
phosphatase SAC1 protein.
ACCESSION BK006944-12
PROTEIN_ID DAA08957.1
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 666816)
AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V.,
Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M.,
Bossier,P. et al.
TITLE Complete DNA sequence of yeast chromosome XI
JOURNAL Nature 369 (6479), 371-378 (1994)
PUBMED 8196765
REFERENCE 2 (bases 1 to 666816)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 666816)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (bases 1 to 666816)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT THIRD PARTY DATABASE: This TPA record uses data from
DDBJ/EMBL/GenBank entries JF740677.1, Z28001.1, Z28002.1, Z28003.1,
Z28004.1, Z28005.1, Z28006.1, Z28007.1, Z28008.1, Z28009.1,
Z28010.1, Z28011.1, Z28012.1, Z28013.1, Z28014.1, Z28015.1,
Z28016.1, Z28017.1, Z28018.1, Z28019.1, Z28020.1, Z28021.1,
Z28022.1, Z28023.1, Z28024.1, Z28025.1, Z28026.1, Z28027.1,
Z28028.1, Z28029.1, Z28031.1, Z28032.1, Z28033.1, Z28034.1,
Z28035.1, Z28038.1, Z28039.1, Z28040.1, Z28041.1, Z28042.1,
Z28043.1, Z28044.1, Z28045.1, Z28046.1, Z28047.1, Z28048.1,
Z28049.1, Z28050.1, Z28051.1, Z28052.1, Z28054.1, Z28055.1,
Z28056.1, Z28057.1, Z28058.1, Z28059.1, Z28060.1, Z28061.1,
Z28062.1, Z28063.1, Z28064.1, Z28065.1, Z28066.1, Z28067.1,
Z28068.1, Z28069.1, Z28070.1, Z28071.1, Z28072.1, Z28073.1,
Z28074.1, Z28075.1, Z28077.1, Z28078.1, Z28079.1, Z28080.1,
Z28081.1, Z28082.1, Z28084.1, Z28085.1, Z28086.1, Z28087.1,
Z28088.1, Z28089.1, Z28090.1, Z28091.1, Z28092.1, Z28093.1,
Z28094.1, Z28095.1, Z28096.1, Z28097.1, Z28098.1, Z28099.1,
Z28100.1, Z28101.1, Z28102.1, Z28103.1, Z28104.1, Z28105.1,
Z28106.1, Z28107.1, Z28108.1, Z28109.1, Z28110.1, Z28111.1,
Z28113.1, Z28114.1, Z28115.1, Z28117.1, Z28118.1, Z28120.1,
Z28121.1, Z28122.1, Z28123.1, Z28125.1, Z28126.1, Z28127.1,
Z28128.1, Z28129.1, Z28130.1, Z28131.1, Z28133.1, Z28134.1,
Z28135.1, Z28137.1, Z28138.1, Z28139.1, Z28140.1, Z28141.1,
Z28142.1, Z28143.1, Z28144.1, Z28145.1, Z28146.1, Z28148.1,
Z28149.1, Z28150.1, Z28151.1, Z28152.1, Z28154.1, Z28155.1,
Z28156.1, Z28157.1, Z28158.1, Z28159.1, Z28160.1, Z28161.1,
Z28162.1, Z28163.1, Z28164.1, Z28165.1, Z28166.1, Z28167.1,
Z28168.1, Z28169.1, Z28171.1, Z28172.1, Z28173.1, Z28174.1,
Z28175.1, Z28176.1, Z28177.1, Z28179.1, Z28180.1, Z28181.1,
Z28182.1, Z28183.1, Z28184.1, Z28185.1, Z28186.1, Z28187.1,
Z28188.1, Z28189.1, Z28190.1, Z28191.1, Z28192.1, Z28193.1,
Z28194.1, Z28195.1, Z28196.1, Z28197.1, Z28198.1, Z28200.1,
Z28201.1, Z28202.1, Z28203.1, Z28204.1, Z28205.1, Z28206.1,
Z28207.1, Z28208.1, Z28209.1, Z28210.1, Z28211.1, Z28212.1,
Z28213.1, Z28214.1, Z28215.1, Z28216.1, Z28217.1, Z28218.1,
Z28219.1, Z28220.1, Z28221.1, Z28222.1, Z28223.1, Z28224.1,
Z28225.1, Z28226.1, Z28227.1, Z28228.1, Z28229.1, Z28230.1,
Z28231.1, Z28232.1, Z28233.1, Z28234.1, Z28235.1, Z28236.1,
Z28237.1, Z28238.1, Z28239.1, Z28240.1, Z28241.1, Z28242.1,
Z28243.1, Z28244.1, Z28245.1, Z28246.1, Z28247.1, Z28248.1,
Z28249.1, Z28250.1, Z28251.1, Z28252.1, Z28253.1, Z28254.1,
Z28255.1, Z28256.1, Z28257.1, Z28258.1, Z28259.1, Z28260.1,
Z28261.1, Z28262.1, Z28263.1, Z28264.1, Z28265.1, Z28266.1,
Z28267.1, Z28268.1, Z28269.1, Z28270.1, Z28271.1, Z28272.1,
Z28273.1, Z28274.1, Z28275.1, Z28276.1, Z28277.1, Z28278.1,
Z28279.1, Z28280.1, Z28281.1, Z28282.1, Z28283.1, Z28284.1,
Z28285.1, Z28286.1, Z28287.1, Z28288.1, Z28289.1, Z28290.1,
Z28291.1, Z28292.1, Z28293.1, Z28294.1, Z28295.1, Z28296.1,
Z28297.1, Z28298.1, Z28299.1, Z28300.1, Z28301.1, Z28302.1,
Z28303.1, Z28304.1, Z28305.1, Z28306.1, Z28307.1, Z28308.1,
Z28309.1, Z28310.1, Z28311.1, Z28312.1, Z28313.1, Z28314.1,
Z28315.1, Z28316.1, Z28317.1, Z28318.1, Z28319.1, Z28320.1,
Z28321.1, Z28322.1, Z28323.1, Z28324.1, Z28325.1, Z28326.1,
Z28327.1, Z28328.1, Z28329.1 and Z28330.1
On Apr 18, 2011 this sequence version replaced BK006944.1.
Chromosome XI sequence was verified by resequencing. The sequence
was mapped to the previous GenBank records except for a 500 bp
region. That region was determined by sequencing a descendant of
the S288C strain, AB972, and is present in GenBank as JF740677.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
FEATURES Qualifiers
source /organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XI"
protein /gene="SAC1"
/locus_tag="YKL212W"
/gene_synonym="RSD1"
/EC_number="3.1.3.64"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:15657391|PMID:8314848]"
/experiment="EXISTENCE:direct assay:GO:0004438
phosphatidylinositol-3-phosphate phosphatase activity
[PMID:10625610]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:11514624|PMID:15657391|PMID:83148
48]"
/experiment="EXISTENCE:direct assay:GO:0005797 Golgi
medial cisterna [PMID:22553352]"
/experiment="EXISTENCE:direct assay:GO:0032541 cortical
endoplasmic reticulum [PMID:30785834]"
/experiment="EXISTENCE:direct assay:GO:0035339 SPOTS
complex [PMID:20182505]"
/experiment="EXISTENCE:direct assay:GO:0043812
phosphatidylinositol-4-phosphate phosphatase activity
[PMID:10625610]"
/experiment="EXISTENCE:direct assay:GO:0046856
phosphatidylinositol dephosphorylation [PMID:10625610]"
/experiment="EXISTENCE:direct assay:GO:0052629
phosphatidylinositol-3,5-bisphosphate 3-phosphatase
activity [PMID:10625610]"
/experiment="EXISTENCE:genetic interaction:GO:0046856
phosphatidylinositol dephosphorylation [PMID:10625610]"
/experiment="EXISTENCE:mutant phenotype:GO:0000139 Golgi
membrane [PMID:15657391]"
/experiment="EXISTENCE:mutant phenotype:GO:0005789
endoplasmic reticulum membrane
[PMID:11514624|PMID:11792713|PMID:15657391]"
/experiment="EXISTENCE:mutant phenotype:GO:0046856
phosphatidylinositol dephosphorylation
[PMID:10625610|PMID:22553352]"
/experiment="EXISTENCE:mutant phenotype:GO:0061909
autophagosome-lysosome fusion [PMID:32693712]"
/experiment="EXISTENCE:mutant phenotype:GO:0072517 host
cell viral assembly compartment [PMID:32269127]"
/note="Phosphatidylinositol phosphate phosphatase; role in
early and medial Golgi PtdIns4P hydrolysis; regulated by
Vps74p interaction; ER localized transmembrane protein
which cycles through the Golgi; role in protein
trafficking, processing, secretion, and cell wall
maintenance; regulates sphingolipid biosynthesis by
modulating PtdIns(4)P metabolism; PtdIns4P PPase activity
is crucial for autophagosome-vacuole fusion during
autophagy; human homolog SACM1L complements autophagy
defects of the null"
/db_xref="SGD:S000001695"
BEGIN
1 MTGPIVYVQN ADGIFFKLAE GKGTNDAVIH LANQDQGVRV LGAEEFPVQG EVVKIASLMG
61 FIKLKLNRYA IIANTVEETG RFNGHVFYRV LQHSIVSTKF NSRIDSEEAE YIKLLELHLK
121 NSTFYFSYTY DLTNSLQRNE KVGPAASWKT ADERFFWNHY LTEDLRNFAH QDPRIDSFIQ
181 PVIYGYAKTV DAVLNATPIV LGLITRRSIF RAGTRYFRRG VDKDGNVGNF NETEQILLAE
241 NPESEKIHVF SFLQTRGSVP IYWAEINNLK YKPNLVLGEN SLDATKKHFD QQKELYGDNY
301 LVNLVNQKGH ELPVKEGYES VVHALNDPKI HYVYFDFHHE CRKMQWHRVK LLIDHLEKLG
361 LSNEDFFHKV IDSNGNTVEI VNEQHSVVRT NCMDCLDRTN VVQSVLAQWV LQKEFESADV
421 VATGSTWEDN APLLTSYQNL WADNADAVSV AYSGTGALKT DFTRTGKRTR LGAFNDFLNS
481 ASRYYQNNWT DGPRQDSYDL FLGGFRPHTA SIKSPFPDRR PVYIQLIPMI ICAALTVLGA
541 TIFFPKDRFT SSKNLLYFAG ASIVLALSTK FMFKNGIQFV NWPKLVDVGF LVVHQTHDKE
601 QQFKGLKYAQ SPKFSKPDPL KRD
//