LOCUS CCP46713.1 619 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv ESX conserved component
EccA2. ESX-2 type VII secretion system protein. Probable
CbxX/CfqX family protein. protein.
ACCESSION AL123456-3991
PROTEIN_ID CCP46713.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="eccA2"
/locus_tag="Rv3884c"
/note="Rv3884c, (MTCY15F10.28), len: 619 aa. eccA2, esx
conserved component, ESX-2 type VII secretion system
protein. Probable CbxX/CfqX protein family, similar to
hypothetical proteins from Mycobacterium leprae e.g.
Q9CD28|Y282_MYCLE|ML2537 (640 aa), FASTA scores: opt:
725,E(): 2.9e-34, (28.95% identity in 587 aa overlap);
O33089|Y2G8_MYCLE|ML0055|MLCB628.18c (belongs to the
CbxX/CfqX family) (573 aa); Q9CBV5|ML1536 (610 aa) FASTA
scores: opt: 648, E(): 7.4e-30, (31.5% identity in 549 aa
overlap). Also similar to proteins belonging to the
CbxX/CfqX family e.g. Q9RKZ2|SC6D7.05c putative CbxX/CfqX
family protein from Streptomyces coelicolor (618 aa) FASTA
scores: opt: 557, E(): 1.3e-24, (28.6% identity in 601 aa
overlap); P27643|SP5K_BACSU|SPOVK|SPOVJ stage V
sporulation protein K from Bacillus subtilis (322 aa)
FASTA scores: opt: 485, E(): 1.1e-20, (35.0% identity in
280 aa overlap) (similarity only at C-terminus);
Q9KAC6|BH2363 stage V sporulation protein K from Bacillus
halodurans (315 aa),FASTA scores: opt: 462, E(): 2.2e-19,
(36.05% identity in 244 aa overlap) (similarity only at
C-terminus); etc. And similar to hypothetical proteins
from Mycobacterium tuberculosis belonging to the CbxX/CfqX
family e.g. O53687|Y282_MYCTU|Rv0282|MT0295|MTV035.10
hypothetical 68.1 KDA protein (631 aa), FASTA scores: opt:
743, E(): 2.6e-35,(29.9% identity in 612 aa overlap);
O69733|Y2G8_MYCTU|Rv3868|MT3981|MTV027.03 hypothetical
62.4 KDA protein (573 aa), FASTA scores: opt: 678, E():
1.3e-31,(31.25% identity in 589 aa overlap);
O53947|YH98_MYCTU|Rv1798|MT1847|MTV049.20 (610 aa) FASTA
scores: opt: 669, E(): 4.6e-31, (30.95% identity in 549 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop). Seems to belong to the CbxX/CfqX family."
/db_xref="EnsemblGenomes-Gn:Rv3884c"
/db_xref="EnsemblGenomes-Tr:CCP46713"
/db_xref="GOA:P9WPH7"
/db_xref="InterPro:IPR000641"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR011990"
/db_xref="InterPro:IPR023835"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR041627"
/db_xref="UniProtKB/Swiss-Prot:P9WPH7"
/inference="protein motif:PROSITE:PS00017"
BEGIN
1 MSRMVDTMGD LLTARRHFDR AMTIKNGQGC VAALPEFVAA TEADPSMADA WLGRIACGDR
61 DLASLKQLNA HSEWLHRETT RIGRTLAAEV QLGPSIGITV TDASQVGLAL SSALTIAGEY
121 AKADALLANR ELLDSWRNYQ WHQLARAFLM YVTQRWPDVL STAAEDLPPQ AIVMPAVTAS
181 ICALAAHAAA HLGQGRVALD WLDRVDVIGH SRSSERFGAD VLTAAIGPAD IPLLVADLAY
241 VRGMVYRQLH EEDKAQIWLS KATINGVLTD AAKEALADPN LRLIVTDERT IASRSDRWDA
301 STAKSRDQLD DDNAAQRRGE LLAEGRELLA KQVGLAAVKQ AVSALEDQLE VRMMRLEHGL
361 PVEGQTNHML LVGPPGTGKT TTAEALGKIY AGMGIVRHPE IREVRRSDFC GHYIGESGPK
421 TNELIEKSLG RIIFMDEFYS LIERHQDGTP DMIGMEAVNQ LLVQLETHRF DFCFIGAGYE
481 DQVDEFLTVN PGLAGRFNRK LRFESYSPVE IVEIGHRYAT PRASQLDDAA REVFLDAVTT
541 IRNYTTPSGQ HGIDAMQNGR FARNVIERAE GFRDTRVVAQ KRAGQPVSVQ DLQIITATDI
601 DAAIRSVCSD NRDMAAIVW
//