LOCUS CCP46700.1 591 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv ESX conserved component
EccCb1. ESX-1 type VII secretion system protein. protein.
ACCESSION AL123456-3978
PROTEIN_ID CCP46700.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="eccCb1"
/gene_synonym="snm2"
/locus_tag="Rv3871"
/note="Rv3871, (MTV027.06), len: 591 aa. EccCb1, esx
conserved component, ESX-1 type VII secretion system
protein, equivalent to Q9CDD7|ML0052 hypothetical protein
from Mycobacterium leprae (597 aa) FASTA scores: opt:
3341,E(): 9.8e-192, (80.85% identity in 596 aa overlap);
and O33086|MLCB628.15c hypothetical protein from
Mycobacterium leprae (597 aa), FASTA scores: opt: 3329,
E(): 5.1e-191,(80.55% identity in 596 aa overlap). And
similar to C-terminal end of others e.g.
Q9Z5I2|ML1543|MLCB596.28 possible SPOIIIE-family membrane
protein from Mycobacterium leprae (1345 aa), FASTA scores:
opt: 601, E(): 5.6e-28,(32.3% identity in 613 aa overlap);
O86653|SC3C3.20c ATP/GTP binding protein from Streptomyces
coelicolor (1321 aa), FASTA scores: opt: 977, E():
2.1e-50, (35.15% identity in 583 aa overlap);
Q9L0T6|SCD35.15c putative cell division-related protein
from Streptomyces coelicolor (1525 aa), FASTA scores: opt:
414, E(): 9e-17, (27.6% identity in 424 aa
overlap);P71068|YUKA YUKA protein from Bacillus subtilis
(1207 aa), FASTA scores: opt: 343, E(): 1.3e-12,(25.8%
identity in 395 aa overlap); etc. And similar to to
C-terminal end of hypothetical proteins from Mycobacterium
tuberculosis e.g. O06264|Rv3447c|MTCY77.19c (1236 aa)
FASTA scores: opt: 845, E(): 1.5e-42, (35.3% identity in
586 aa overlap); O53689|Rv0284|MTV035.12 (1330 aa) FASTA
scores: opt: 646, E(): 1.2e-30, (33.35% identity in 606 aa
overlap); O53935|Rv1784|MTV049.06 (932 aa) FASTA scores:
opt: 589, E(): 2.1e-27, (33.1% identity in 619 aa
overlap); etc. Contains 2 X PS00017 ATP/GTP-binding site
motif A (P-loop). Note some similarity (with hypothetical
proteins from Mycobacterium tuberculosis and P71068|YUKA)
continues in upstream ORF MTV027.05."
/db_xref="EnsemblGenomes-Gn:Rv3871"
/db_xref="EnsemblGenomes-Tr:CCP46700"
/db_xref="GOA:P9WNB1"
/db_xref="InterPro:IPR002543"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR023837"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WNB1"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MTAEPEVRTL REVVLDQLGT AESRAYKMWL PPLTNPVPLN ELIARDRRQP LRFALGIMDE
61 PRRHLQDVWG VDVSGAGGNI GIGGAPQTGK STLLQTMVMS AAATHSPRNV QFYCIDLGGG
121 GLIYLENLPH VGGVANRSEP DKVNRVVAEM QAVMRQRETT FKEHRVGSIG MYRQLRDDPS
181 QPVASDPYGD VFLIIDGWPG FVGEFPDLEG QVQDLAAQGL AFGVHVIIST PRWTELKSRV
241 RDYLGTKIEF RLGDVNETQI DRITREIPAN RPGRAVSMEK HHLMIGVPRF DGVHSADNLV
301 EAITAGVTQI ASQHTEQAPP VRVLPERIHL HELDPNPPGP ESDYRTRWEI PIGLRETDLT
361 PAHCHMHTNP HLLIFGAAKS GKTTIAHAIA RAICARNSPQ QVRFMLADYR SGLLDAVPDT
421 HLLGAGAINR NSASLDEAVQ ALAVNLKKRL PPTDLTTAQL RSRSWWSGFD VVLLVDDWHM
481 IVGAAGGMPP MAPLAPLLPA AADIGLHIIV TCQMSQAYKA TMDKFVGAAF GSGAPTMFLS
541 GEKQEFPSSE FKVKRRPPGQ AFLVSPDGKE VIQAPYIEPP EEVFAAPPSA G
//