LOCUS CCP46653.1 511 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Conserved polyketide
synthase associated protein PapA1 protein.
ACCESSION AL123456-3931
PROTEIN_ID CCP46653.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="papA1"
/locus_tag="Rv3824c"
/note="Rv3824c, (MTCY409.06), len: 511 aa. papA1,
conserved polyketide synthase (PKS) associated protein,
highly similar to Q49618|PAPA3|ML1230|B1170_C1_180
PKS-associated protein A3 from Mycobacterium leprae (471
aa), FASTA scores: opt: 1879, E(): 7.1e-111, (55.5%
identity in 465 aa overlap). Also similar to
Q9F2R3|SCD65.19c hypothetical 52.8 KDA protein from
Streptomyces coelicolor (473 aa),FASTA scores: opt: 476,
E(): 1.7e-22, (26.7% identity in 464 aa overlap); and
similar in part to Q09164|SIMA|CYSYN cyclosporin
synthetase from Tolypocladium inflatum (15281 aa) FASTA
scores: opt: 238, E(): 2.8e-06, (22.35% identity in 371 aa
overlap). Also highly similar to other PKS-associated
proteins from Mycobacterium tuberculosis;
O50438|PAPA3|Rv1182|MTV005.18 (472 aa), FASTA scores: opt:
1862, E(): 8.4e-110, (55.95% identity in 470 aa overlap);
and upstream ORF O07803|PAPA2|Rv3820c|MTCY409.10 (468 aa)
FASTA scores: opt: 1664, E(): 2.5e-97, (53.9% identity in
462 aa overlap). Contains PS00453 FKBP-type
peptidyl-prolyl cis-trans isomerase signature 1."
/db_xref="EnsemblGenomes-Gn:Rv3824c"
/db_xref="EnsemblGenomes-Tr:CCP46653"
/db_xref="GOA:P9WIK9"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR023213"
/db_xref="UniProtKB/Swiss-Prot:P9WIK9"
/inference="protein motif:PROSITE:PS00453"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MRIGPVELSA VKDWDPAPGV LVSWHPTPAS CAKALAAPVS AVPPSYVQAR QIRSFSEQAA
61 RGLDHSRLLI ASVEVFGHCD LRAMTYVINA HLRRHDTYRS WFELRDTDHI VRHSIADPAD
121 IEFVPTTHGE MTSADLRQHI VATPDSLHWD CFSFGVIQRA DSFTFYASID HLHADGQFVG
181 VGLMEFQSMY TALIMGEPPI GLSEAGSYVD FCVRQHEYTS ALTVDSPEVR AWIDFAEINN
241 GTFPEFPLPL GDPSVRCGGD LLSMMLMDEQ QTQRFESACM AANARFIGGM LACIAIAIHE
301 LTGADTYFGI TPKDIRTPAD LMTQGWFTGQ IPVTVPVAGL SFNEIARIAQ TSFDTGADLA
361 KVPFERVVEL SPSLRRPQPL FSLVNFFDAQ VGPLSAVTKL FEGLNVGTYS DGRVTYPLST
421 MVGRFDETAA SVLFPDNPVA RESVTAYLRA IRSVCMRIAN GGTAERVGNV VALSPGRRNN
481 IERMTWRSCR AGDFIDICNL KVANVTVDRE A
//