LOCUS CCP46632.1 299 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Secreted MPT51/MPB51
antigen protein FbpD (MPT51/MPB51 antigen 85 complex C)
(AG58C) (mycolyl transferase 85C) (fibronectin-binding
protein C) (85C) protein.
ACCESSION AL123456-3910
PROTEIN_ID CCP46632.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="fbpD"
/gene_synonym="fbpC1"
/gene_synonym="mpb51"
/gene_synonym="mpt51"
/locus_tag="Rv3803c"
/note="Rv3803c, (MT3910, MTV026.08c), len: 299 aa. FbpD
(alternate gene names: mpt51, mpb51, fbpC1), secreted
MPB51/MPT51 antigen protein (fibronectin-binding protein
C) (mycolyl transferase 85C) (see citations below),
identical to Q48923|MPT51|MPB51 antigen precursor from
Mycobacterium bovis (299 aa), FASTA scores: opt: 2093,
E(): 1.5e-112,(100.0% identity in 299 aa overlap) (see
Ohara et al.,1995); and highly similar to other
Mycobacterial antigen precursors e.g.
Q05868|MPT5_MYCLE|MPT51|ML0098 MPT51 antigen precursor
from Mycobacterium leprae (301 aa), FASTA scores: opt:
1624, E(): 9.8e-86, (77.8% identity in 302 aa overlap);
O52972|A85C_MYCAV|FBPC antigen 85-C precursor
(fibronectin-binding protein C) from Mycobacterium avium
(352 aa), FASTA scores: opt: 753, E(): 6.6e-36, (41.5%
identity in 315 aa overlap); P21160|A85B_MYCKA antigen
85-B precursor (fibronectin-binding protein B) from
Mycobacterium kansasii (325 aa), FASTA scores: opt:
574,E(): 1.1e-25, (37.55% identity in 309 aa overlap);
P12942|A85B_MYCBO antigen 85-B precursor from
Mycobacterium bovis (323 aa), FASTA scores: opt: 572, E():
1.4e-25,(39.85% identity in 291 aa overlap); etc. Also
similar to P31953|A85C_MYCTU|FBPC|MPT45|Rv0129c|MTCI5.03c|
FBPC2 secreted antigen 85-C (mycolyl transferase 85C)
(fibronectin-binding protein C) from Mycobacterium
tuberculosis (340 aa), FASTA scores: opt: 751, E():
8.4e-36, (40.65% identity in 310 aa overlap);
P17944|A85A_MYCTU|FBPA|MPT44|Rv3804c|MT3911|MTV026.09c
secreted antigen 85-a (mycolyl transferase 85A)
(fibronectin-binding protein A) from Mycobacterium
tuberculosis (338 aa), FASTA scores: opt: 592, E():
1e-26,(39.05% identity in 302 aa overlap); etc. Contains
PS00178 Aminoacyl-transfer RNA synthetases class-I
signature. Note that the secreted protein MPB51 is one of
the major proteins in the culture filtrate of
Mycobacterium bovis BCG. Note that overexpression in an
FbpC-deficient M. tuberculosis clinical isolate has no
effect on the amount of cell wall-linked mycolates (See
Puech et al., 2002)."
/db_xref="EnsemblGenomes-Gn:Rv3803c"
/db_xref="EnsemblGenomes-Tr:CCP46632"
/db_xref="GOA:P9WQN7"
/db_xref="InterPro:IPR000801"
/db_xref="InterPro:IPR029058"
/db_xref="PDB:1R88"
/db_xref="UniProtKB/Swiss-Prot:P9WQN7"
/inference="protein motif:PROSITE:PS00178"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MKGRSALLRA LWIAALSFGL GGVAVAAEPT AKAAPYENLM VPSPSMGRDI PVAFLAGGPH
61 AVYLLDAFNA GPDVSNWVTA GNAMNTLAGK GISVVAPAGG AYSMYTNWEQ DGSKQWDTFL
121 SAELPDWLAA NRGLAPGGHA AVGAAQGGYG AMALAAFHPD RFGFAGSMSG FLYPSNTTTN
181 GAIAAGMQQF GGVDTNGMWG APQLGRWKWH DPWVHASLLA QNNTRVWVWS PTNPGASDPA
241 AMIGQAAEAM GNSRMFYNQY RSVGGHNGHF DFPASGDNGW GSWAPQLGAM SGDIVGAIR
//