LOCUS CCP46591.1 475 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible two component
sensor kinase TcrY protein.
ACCESSION AL123456-3869
PROTEIN_ID CCP46591.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="tcrY"
/locus_tag="Rv3764c"
/note="Rv3764c, (MTV025.112c), len: 475 aa. Possible
tcrY,histidine protein kinase, part of a two-component
regulatory system, similar to others e.g.
Q9ADN6|2SC10A7.25 putative two component system histidine
kinase from Streptomyces coelicolor (524 aa), FASTA
scores: opt: 1332,E(): 5.4e-70, (49.9% identity in 477 aa
overlap); Q9L3C1|KB|CAC42479 putative histidine kinase
from Amycolatopsis mediterranei (469 aa), FASTA scores:
opt: 515, E(): 1.4e-22, (36.1% identity in 313 aa
overlap); P72560 histidine protein kinase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(438 aa), FASTA scores: opt: 480, E(): 1.4e-20, (40.1%
identity in 232 aa overlap);
P30847|P76401|BAES_ECOLI|B2078 sensor protein from
Escherichia coli strain K12 (467 aa); etc. Also similar to
others from Mycobacterium tuberculosis e.g.
P96368|Rv1032c|MTCY10G2.17 (509 aa), FASTA scores: opt:
1007, E(): 4e-51, (43.5% identity in 416 aa overlap); and
P71815|Rv0758|MTCY369.03 (485 aa), FASTA scores: opt:
738,E(): 1.6e-35, (28.6% identity in 438 aa overlap).
Equivalent to AAK48235 from Mycobacterium tuberculosis
strain CDC1551 (506 aa) but shorter 31 aa."
/db_xref="EnsemblGenomes-Gn:Rv3764c"
/db_xref="EnsemblGenomes-Tr:CCP46591"
/db_xref="GOA:O69729"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:O69729"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MGITAATEMA LRRHLVAQLD NQLGGTSYRS VLMYPEKMPR PPWRHETHNY IRSGPGPRFL
61 DAPGQPAGMV AAVVSDGTTV AAGYLTGSGS RAALTSTGRS QLERIAGSRT PLTLDLDGLG
121 RYRVLAAPSR NGHDVIVTGL SMGNVDATML QMLIIFGIVT VIALVAATTA GIVIIKRALA
181 PLRRVAQTAS EVVDLPLDRG EVKLPVRVPE PDANPSTEVG QLGSALNRML DHIAAALSAR
241 QASETCVRQF VADASHELRT PLAAIRGYTE LTQRIGDDPE AVAHAMSRVA SETERITRLV
301 EDLLLLARLD SGRPLERGPV DMSRLAVDAV SDAHVAGPDH QWALDLPPEP VVIPGDAARL
361 HQVVTNLLAN ARVHTGPGTI VTTRLSTGPT HVVLQVIDNG PGIPAALQSE VFERFARGDT
421 SRSRQAGSTG LGLAIVSAVV KAHNGTITVS SSPGYTEFAV RLPLDGWQPL ESSPR
//