LOCUS CCP46546.1 420 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible fatty acid synthase
protein.
ACCESSION AL123456-3824
PROTEIN_ID CCP46546.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/locus_tag="Rv3720"
/note="Rv3720, (MTV025.068), len: 420 aa. Possible
fatty-acyl-phospholipid synthase, equivalent to
Q9CB74|ML2334 (alias O69515|MLCB2407.16c, 439 aa)
hypothetical protein from Mycobacterium leprae (420 aa)
FASTA scores: opt: 2508, E(): 4.7e-153, (86.45% identity
in 420 aa overlap). Also similar (especially at the
C-terminus) to various fatty-acid synthases (principally
cyclopropane-fatty-acyl-phospholipid synthases) and
hypothetical proteins e.g. Q9KZ58|SCE25.32c putative fatty
acid synthase from Streptomyces coelicolor (438 aa), FASTA
scores: opt: 1101, E(): 5.5e-63, (46.1% identity in 425 aa
overlap); P31049|YLP3_PSEPU hypothetical 44.7 KDA protein
from Pseudomonas putida (394 aa), FASTA scores: opt:
810,E(): 2.1e-44, (46.4% identity in 293 aa overlap);
Q9HT28|PA5546 hypothetical protein from Pseudomonas
aeruginosa (394 aa), FASTA scores: opt: 804, E():
5.2e-44,(40.7% identity in 371 aa overlap); Q9RSD7|DR2187
putative cyclopropane-fatty-acyl-phospholipid synthase
from Deinococcus radiodurans (462 aa), FASTA scores: opt:
747,E(): 2.6e-40, (35.95% identity in 409 aa overlap);
BAB50831|Q98ET6|MLL4091
cyclopropane-fatty-acyl-phospholipid synthase from
Rhizobium loti (Mesorhizobium loti) (422 aa), FASTA
scores: opt: 674, E(): 1.1e-35, (39.1% identity in 284 aa
overlap); P30010|CFA_ECOLI|CDFA|B1661
cyclopropane-fatty-acyl-phospholip synthase from
Escherichia coli strain K12 (381 aa), FASTA scores: opt:
530, E(): 1.7e-26, (33.65% identity in 312 aa overlap);
etc. Also similar to other proteins from Mycobacterium
tuberculosis e.g. CMA2|Rv0503c|MTCY20G9.30c (302 aa);
P96911|Rv0621|MTCY20H10 (354 aa);
O50416|LPQD|Rv3390|MTV004.48 (236 aa); etc."
/db_xref="EnsemblGenomes-Gn:Rv3720"
/db_xref="EnsemblGenomes-Tr:CCP46546"
/db_xref="GOA:O69687"
/db_xref="InterPro:IPR003333"
/db_xref="InterPro:IPR029063"
/db_xref="UniProtKB/Swiss-Prot:O69687"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MAEILEIFTA TGQHPLKFTA YDGSTAGQDD ATLGLDLRTP RGATYLATAP GELGLARAYV
61 SGDLQAHGVH PGDPYELLKT LTERVDFKRP SARVLANVVR SIGVEHILPI APPPQEARPR
121 WRRMANGLLH SKTRDAEAIH HHYDVSNNFY EWVLGPSMTY TCAVFPNAEA SLEQAQENKY
181 RLIFEKLRLE PGDRLLDVGC GWGGMVRYAA RRGVRVIGAT LSAEQAKWGQ KAVEDEGLSD
241 LAQVRHSDYR DVAETGFDAV SSIGLTEHIG VKNYPFYFGF LKSKLRTGGL LLNHCITRHD
301 NRSTSFAGGF TDRYVFPDGE LTGSGRITTE IQQVGLEVLH EENFRHHYAM TLRDWCGNLV
361 EHWDDAVAEV GLPTAKVWGL YMAASRVAFE RNNLQLHHVL ATKVDPRGDD SLPLRPWWQP
//