LOCUS CCP46469.1 934 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv DNA topoisomerase I TopA
(omega-protein) (relaxing enzyme) (untwisting enzyme)
(swivelase) (type I DNA topoisomerase) (nicking-closing
enzyme) (TOPO I) protein.
ACCESSION AL123456-3747
PROTEIN_ID CCP46469.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="topA"
/locus_tag="Rv3646c"
/note="Rv3646c, (MTCY15C10.06), len: 934 aa. TopA, DNA
topoisomerase I (see citations below), equivalent to
O69548|TOP1_MYCLE|TOPA|ML0200|MLCB2548.31c DNA
topoisomerase I from Mycobacterium leprae (947 aa) FASTA
scores: opt: 5150, E(): 0, (84.6% identity in 936 aa
overlap). Also highly similar to many e.g.
Q9X909|TOP1_STRCO|TOPA|SCH5.06c from Streptomyces
coelicolor (952 aa), FASTA scores: opt: 2754, E():
1.3e-153, (61.3% identity in 928 aa overlap);
P73810|TOP1_SYNY3|TOPA|SLR2058 from Synechocystis sp.
strain PCC 6803 (898 aa), FASTA scores: opt: 1442, E():
9.1e-77, (47.15% identity in 927 aa overlap);
P47368|TOP1_MYCGE|TOPA|MG122 from Mycoplasma genitalium
(709 aa), FASTA scores: opt: 865, E(): 4.8e-43, (30.3%
identity in 736 aa overlap);
P06612|TOP1_ECOLI|TOPA|SUPX|B1274 from Escherichia coli
strain K12 (865 aa), FASTA scores: opt: 397, E(): 0,
(39.6% identity in 704 aa overlap); etc. Belongs to
prokaryotic type I/III topoisomerase family."
/db_xref="EnsemblGenomes-Gn:Rv3646c"
/db_xref="EnsemblGenomes-Tr:CCP46469"
/db_xref="GOA:P9WG49"
/db_xref="InterPro:IPR000380"
/db_xref="InterPro:IPR003601"
/db_xref="InterPro:IPR003602"
/db_xref="InterPro:IPR005733"
/db_xref="InterPro:IPR006171"
/db_xref="InterPro:IPR013497"
/db_xref="InterPro:IPR013824"
/db_xref="InterPro:IPR013825"
/db_xref="InterPro:IPR013826"
/db_xref="InterPro:IPR023405"
/db_xref="InterPro:IPR023406"
/db_xref="InterPro:IPR025589"
/db_xref="InterPro:IPR028612"
/db_xref="InterPro:IPR034149"
/db_xref="PDB:5D5H"
/db_xref="PDB:5UJ1"
/db_xref="PDB:5UJY"
/db_xref="PDB:6CQ2"
/db_xref="PDB:6CQI"
/db_xref="UniProtKB/Swiss-Prot:P9WG49"
/inference="protein motif:PROSITE:PS00396"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MADPKTKGRG SGGNGSGRRL VIVESPTKAR KLASYLGSGY IVESSRGHIR DLPRAASDVP
61 AKYKSQPWAR LGVNVDADFE PLYIISPEKR STVSELRGLL KDVDELYLAT DGDREGEAIA
121 WHLLETLKPR IPVKRMVFHE ITEPAIRAAA EHPRDLDIDL VDAQETRRIL DRLYGYEVSP
181 VLWKKVAPKL SAGRVQSVAT RIIVARERDR MAFRSAAYWD ILAKLDASVS DPDAAPPTFS
241 ARLTAVAGRR VATGRDFDSL GTLRKGDEVI VLDEGSATAL AAGLDGTQLT VASAEEKPYA
301 RRPYPPFMTS TLQQEASRKL RFSAERTMSI AQRLYENGYI TYMRTDSTTL SESAINAART
361 QARQLYGDEY VAPAPRQYTR KVKNAQEAHE AIRPAGETFA TPDAVRRELD GPNIDDFRLY
421 ELIWQRTVAS QMADARGMTL SLRITGMSGH QEVVFSATGR TLTFPGFLKA YVETVDELVG
481 GEADDAERRL PHLTPGQRLD IVELTPDGHA TNPPARYTEA SLVKALEELG IGRPSTYSSI
541 IKTIQDRGYV HKKGSALVPS WVAFAVTGLL EQHFGRLVDY DFTAAMEDEL DEIAAGNERR
601 TNWLNNFYFG GDHGVPDSVA RSGGLKKLVG INLEGIDARE VNSIKLFDDT HGRPIYVRVG
661 KNGPYLERLV AGDTGEPTPQ RANLSDSITP DELTLQVAEE LFATPQQGRT LGLDPETGHE
721 IVAREGRFGP YVTEILPEPA ADAAAAAQGV KKRQKAAGPK PRTGSLLRSM DLQTVTLEDA
781 LRLLSLPRVV GVDPASGEEI TAQNGRYGPY LKRGNDSRSL VTEDQIFTIT LDEALKIYAE
841 PKRRGRQSAS APPLRELGTD PASGKPMVIK DGRFGPYVTD GETNASLRKG DDVASITDER
901 AAELLADRRA RGPAKRPARK AARKVPAKKA AKRD
//