LOCUS CCP46457.1 314 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv UDP-glucose 4-epimerase
GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (
uridine diphosphate galactose 4-epimerase) (uridine diphospho-
galactose 4-epimerase) protein.
ACCESSION AL123456-3735
PROTEIN_ID CCP46457.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="galE1"
/gene_synonym="rmlB2"
/locus_tag="Rv3634c"
/note="Rv3634c, (MTCY15C10.18), len: 314 aa.
GalE1,UDP-glucose 4-epimerase (see citations below),
equivalent to O69544|ML0204|RMLB2|MLCB2548.27c putative
sugar dehydratase (putative sugar-nucleotide dehydratase)
from Mycobacterium leprae (319 aa), FASTA scores: opt:
1798,E(): 8.2e-100, (86.4% identity in 309 aa overlap).
Also similar to other UDP-glucose 4-epimerases e.g.
Q9WYX9|TM0509 from Thermotoga maritima (309 aa) FASTA
scores: opt: 877, E(): 4.8e-45, (45.8% identity in 308 aa
overlap); Q57664|GALE_METJA|MJ0211 from Methanococcus
jannaschii (305 aa), FASTA scores: opt: 792, E():
5.4e-40,(42.05% identity in 309 aa overlap); Q9K6S7|BH3649
from Bacillus halodurans (311 aa), FASTA scores: opt: 723,
E(): 7e-36, (40.5% identity in 316 aa overlap);
Q9HSV1|GALE2|VNG0063G from Halobacterium sp. strain NRC-1
(328 aa), FASTA scores: opt: 597, E(): 2.3e-28, (36.35%
identity in 322 aa overlap); etc. Contains short-chain
alcohol dehydrogenase family signature (PS00061) but this
maynot be significant. Belongs to the sugar epimerase
family. Note that previously known as rmlB2, a
dTDP-glucose 4,6-dehydratase (see Ma et al., 2001)."
/db_xref="EnsemblGenomes-Gn:Rv3634c"
/db_xref="EnsemblGenomes-Tr:CCP46457"
/db_xref="GOA:P9WN67"
/db_xref="InterPro:IPR016040"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P9WN67"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MRALVTGAAG FIGSTLVDRL LADGHSVVGL DNFATGRATN LEHLADNSAH VFVEADIVTA
61 DLHAILEQHR PEVVFHLAAQ IDVRRSVADP QFDAAVNVIG TVRLAEAARQ TGVRKIVHTS
121 SGGSIYGTPP EYPTPETAPT DPASPYAAGK VAGEIYLNTF RHLYGLDCSH IAPANVYGPR
181 QDPHGEAGVV AIFAQALLSG KPTRVFGDGT NTRDYVFVDD VVDAFVRVSA DVGGGLRFNI
241 GTGKETSDRQ LHSAVAAAVG GPDDPEFHPP RLGDLKRSCL DIGLAERVLG WRPQIELADG
301 VRRTVEYFRH KHTD
//