LOCUS       CCP46437.1               184 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv ESX-1 secretion-associated
            protein EspD protein.
ACCESSION   AL123456-3715
PROTEIN_ID  CCP46437.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="espD"
                     /gene_synonym="snm10"
                     /locus_tag="Rv3614c"
                     /note="Rv3614c, (MTCY07H7B.08), len: 184 aa. EspD, ESX-1
                     secretion-associated protein, equivalent to
                     Q49730|ML0407|B1620_C3_264|MLCL383.03 hypothetical 24.2
                     KDA protein from Mycobacterium leprae (216 aa) FASTA
                     scores: opt: 899, E(): 1.7e-51, (71.3% identity in 188 aa
                     overlap); and similar to two hypothetical proteins from
                     Mycobacterium leprae: Q9CDD6|ML0056 (169 aa), FASTA
                     scores: opt: 285,E(): 1.2e-11, (38.35% identity in 172 aa
                     overlap); and O33090|MLCB628.19c (338 aa), FASTA scores:
                     opt: 289, E(): 1.2e-11, (38.95% identity in 172 aa
                     overlap). Also highly similar to O69732|Rv3867|MTV027.02
                     hypothetical 19.9 KDA protein from Mycobacterium
                     tuberculosis (183 aa), FASTA scores: opt: 563, E(): 1e-29,
                     (54.9% identity in 173 aa overlap). Rv3614c and Rv3882c
                     interact, by yeast two-hybrid analysis (See MacGurn et
                     al., 2005). EspD|Rv3614c is still secreted by M.
                     tuberculosis H37Rv and Erdman ESX-1 secretion system
                     mutants, but at levels lower than in wild-type (See Chen
                     et al., 2012)."
                     /db_xref="EnsemblGenomes-Gn:Rv3614c"
                     /db_xref="EnsemblGenomes-Tr:CCP46437"
                     /db_xref="GOA:P9WJD5"
                     /db_xref="UniProtKB/Swiss-Prot:P9WJD5"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MDLPGNDFDS NDFDAVDLWG ADGAEGWTAD PIIGVGSAAT PDTGPDLDNA HGQAETDTEQ
       61 EIALFTVTNP PRTVSVSTLM DGRIDHVELS ARVAWMSESQ LASEILVIAD LARQKAQSAQ
      121 YAFILDRMSQ QVDADEHRVA LLRKTVGETW GLPSPEEAAA AEAEVFATRY SDDCPAPDDE
      181 SDPW
//