LOCUS CCP46433.1 760 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Membrane-bound protease
FtsH (cell division protein) protein.
ACCESSION AL123456-3711
PROTEIN_ID CCP46433.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="ftsH"
/locus_tag="Rv3610c"
/note="Rv3610c, (MT3714, MTCY07H7B.12), len: 760 aa.
FtsH,membrane-bound protease (cell division protein) (see
citations below), equivalent to Q9CD58|FTSH_MYCLE|ML0222
(alias O69532|FTSH) cell division protein FTSH homolog
from Mycobacterium leprae (787 aa), FASTA scores: opt:
4388,E(): 9.6e-205, (87.2% identity in 790 aa overlap).
Also highly similar to many FTSH proteins e.g. O52395|FTSH
from Mycobacterium smegmatis (769 aa), FASTA scores: opt:
3976,E(): 7.6e-185, (82.4% identity in 761 aa overlap);
Q9X8I4|SCE9.11c from Streptomyces coelicolor (668
aa),FASTA scores: opt: 2417, E(): 1.4e-109, (57.2%
identity in 668 aa overlap); P72991|FTH4_SYNY3|SLR1604
from Synechocystis sp. strain PCC 6803 (616 aa), FASTA
scores: opt: 1926, E(): 7.2e-86, (49.35% identity in 612
aa overlap); P28691|FTSH_ECOLI|HFLB|MRSC|TOLZ|B3178 from
Escherichia coli strain K12 (644 aa), FASTA scores: opt:
1859, E(): 1.3e-82, (48.95% identity in 605 aa overlap);
etc. Contains PS00017 ATP/GTP-binding site motif A
(P-loop), and PS00674 AAA-protein family signature.
Belongs to the AAA family of ATPases and peptidase family
M41 (zinc metalloprotease). Cofactor: binds one zinc ion
(potential). Conserved in M. tuberculosis, M. leprae, M.
bovis and M. avium paratuberculosis; predicted to be
essential for in vivo survival and pathogenicity (See
Ribeiro-Guimaraes and Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv3610c"
/db_xref="EnsemblGenomes-Tr:CCP46433"
/db_xref="GOA:P9WQN3"
/db_xref="InterPro:IPR000642"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR003959"
/db_xref="InterPro:IPR003960"
/db_xref="InterPro:IPR005936"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR037219"
/db_xref="InterPro:IPR041569"
/db_xref="UniProtKB/Swiss-Prot:P9WQN3"
/inference="protein motif:PROSITE:PS00674"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MNRKNVTRTI TAIAVVVLLG WSFFYFSDDT RGYKPVDTSV AITQINGDNV KSAQIDDREQ
61 QLRLILKKGN NETDGSEKVI TKYPTGYAVD LFNALSAKNA KVSTVVNQGS ILGELLVYVL
121 PLLLLVGLFV MFSRMQGGAR MGFGFGKSRA KQLSKDMPKT TFADVAGVDE AVEELYEIKD
181 FLQNPSRYQA LGAKIPKGVL LYGPPGTGKT LLARAVAGEA GVPFFTISGS DFVEMFVGVG
241 ASRVRDLFEQ AKQNSPCIIF VDEIDAVGRQ RGAGLGGGHD EREQTLNQLL VEMDGFGDRA
301 GVILIAATNR PDILDPALLR PGRFDRQIPV SNPDLAGRRA VLRVHSKGKP MAADADLDGL
361 AKRTVGMTGA DLANVINEAA LLTARENGTV ITGPALEEAV DRVIGGPRRK GRIISEQEKK
421 ITAYHEGGHT LAAWAMPDIE PIYKVTILAR GRTGGHAVAV PEEDKGLRTR SEMIAQLVFA
481 MGGRAAEELV FREPTTGAVS DIEQATKIAR SMVTEFGMSS KLGAVKYGSE HGDPFLGRTM
541 GTQPDYSHEV AREIDEEVRK LIEAAHTEAW EILTEYRDVL DTLAGELLEK ETLHRPELES
601 IFADVEKRPR LTMFDDFGGR IPSDKPPIKT PGELAIERGE PWPQPVPEPA FKAAIAQATQ
661 AAEAARSDAG QTGHGANGSP AGTHRSGDRQ YGSTQPDYGA PAGWHAPGWP PRSSHRPSYS
721 GEPAPTYPGQ PYPTGQADPG SDESSAEQDD EVSRTKPAHG
//