LOCUS CCP46429.1 188 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv 2-amino-4-hydroxy-6-
hydroxymethyldihydropteridinepyrophosphokinase FolK (7,
8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK)
(6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase)
(PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin- diphosphokinase
) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase)
protein.
ACCESSION AL123456-3707
PROTEIN_ID CCP46429.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="folK"
/locus_tag="Rv3606c"
/note="Rv3606c, (MTCY07H7B.16), len: 188 aa. Probable
folK,2-amino-4-hydroxy-6-hydroxymethyldihydropterine
pyrophosphokinase, equivalent to
O69528|HPPK_MYCLE|folk|ML0226\MLCB2548.05c
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
pyrophosphokinase from Mycobacterium leprae (191 aa) FASTA
scores: opt: 772, E(): 1.2e-44, (63.15% identity in 190 aa
overlap). Also similar to many e.g.
P71512|HPPK_METEX|folk|FOLA from Methylobacterium
extorquens (158 aa), FASTA scores: opt: 292, E():
1.4e-12,(36.85% identity in 171 aa overlap);
O33726|HPPK_STRPY|folk|SPY1100 from Streptococcus pyogenes
(166 aa), FASTA scores: opt: 234, E(): 1.1e-08, (34.3%
identity in 175 aa overlap); Q9X8I1|SCE9.08 from
Streptomyces coelicolor (203 aa), FASTA scores: opt:
232,E(): 1.7e-08, (43.25% identity in 185 aa overlap);
P26281|HPPK_ECOLI|folk|B0142 from Escherichia coli strain
K12 (158 aa), FASTA scores: opt: 198, E(): 2.6e-06,
(32.85% identity in 143 aa overlap); etc. Belongs to the
HppK family."
/db_xref="EnsemblGenomes-Gn:Rv3606c"
/db_xref="EnsemblGenomes-Tr:CCP46429"
/db_xref="GOA:P9WNC7"
/db_xref="InterPro:IPR000550"
/db_xref="InterPro:IPR035907"
/db_xref="UniProtKB/Swiss-Prot:P9WNC7"
BEGIN
1 MTRVVLSVGS NLGDRLARLR SVADGLGDAL IAASPIYEAD PWGGVEQGQF LNAVLIADDP
61 TCEPREWLRR AQEFERAAGR VRGQRWGPRN LDVDLIACYQ TSATEALVEV TARENHLTLP
121 HPLAHLRAFV LIPWIAVDPT AQLTVAGCPR PVTRLLAELE PADRDSVRLF RPSFDLNSRH
181 PVSRAPES
//