LOCUS       CCP46321.1               400 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Mce-family protein Mce4A protein.
ACCESSION   AL123456-3599
PROTEIN_ID  CCP46321.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="mce4A"
                     /gene_synonym="mce4"
                     /locus_tag="Rv3499c"
                     /note="Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs
                     to 24-membered Mycobacterium tuberculosis Mce protein
                     family (see citations below), highly similar to
                     Mycobacterium tuberculosis proteins
                     P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa);
                     O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and
                     O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar
                     to others e.g. Q9F356|SC8A2.07c putative secreted protein
                     from Streptomyces coelicolor (418 aa), FASTA scores: opt:
                     619, E(): 7.8e-30, (32.4% identity in 352 aa overlap);
                     Q9S4U5|MCE1 mycobacterial cell entry protein from
                     Mycobacterium bovis BCG (454 aa), FASTA scores: opt:
                     529,E(): 2.1e-24, (30.35% identity in 448 aa overlap);
                     Q9CD14|MCE1A|ML2589 from Mycobacterium leprae (441
                     aa),FASTA scores: opt: 515, E(): 1.4e-23, (28.35% identity
                     in 430 aa overlap); etc. Contains a possible N-terminal
                     signal sequence. Note that previously known as mce4.
                     Predicted to be an outer membrane protein (See Song et
                     al., 2008)."
                     /db_xref="EnsemblGenomes-Gn:Rv3499c"
                     /db_xref="EnsemblGenomes-Tr:CCP46321"
                     /db_xref="GOA:I6YC99"
                     /db_xref="InterPro:IPR003399"
                     /db_xref="InterPro:IPR005693"
                     /db_xref="InterPro:IPR024516"
                     /db_xref="UniProtKB/TrEMBL:I6YC99"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MSGGGSRRTS VRVAAALLAG LMVGSAVLTY LSYTAAFTST DTVTVSSPRA GLVMEKGAKV
       61 KYRGIQVGKV TDISYSGNQA RLKLAIDSGE MGFIPSNATV RIAGNTIFGA KSVEFIPPKT
      121 PSPKPLSPNA HVAASQVQLE VNTLFQSLID LLHKIDPLET NATLSALSEG LRGHGDDLGA
      181 LLSGLNTLTR QANPKLPALQ EDFRKAAVVA NVYADAAGDL NTVFDNLPTI NKTIVDQKDN
      241 LNDTLLATIG LSNNAYETLA PAEQNFIDAI NRLRAPLKVT SDYSPVFGCL FKGIARGVKE
      301 FAPLIGVRKA GLFTSSSFVL GAPSYTYPES LPIVNASGGP NCRGLPDIPT KQTGGSFYRA
      361 PFLVTDNALI PYQPFTELQV DAPSTLQFLF NGAFAERDDF
//