LOCUS CCP46318.1 451 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Mce-family protein Mce4D protein. ACCESSION AL123456-3596 PROTEIN_ID CCP46318.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="mce4D" /locus_tag="Rv3496c" /note="Rv3496c, (MTV023.03c), len: 451 aa. Mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 putative secreted protein from Mycobacterium leprae (531 aa), FASTA scores: opt: 837,E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c putative secreted protein from Streptomyces coelicolor (337 aa), FASTA scores: opt: 606,E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. Hydrophobic region at N-terminus. Predicted to be an outer membrane protein (See Song et al., 2008)." /db_xref="EnsemblGenomes-Gn:Rv3496c" /db_xref="EnsemblGenomes-Tr:CCP46318" /db_xref="GOA:I6XHD6" /db_xref="InterPro:IPR003399" /db_xref="InterPro:IPR005693" /db_xref="InterPro:IPR024516" /db_xref="UniProtKB/TrEMBL:I6XHD6" BEGIN 1 MMGRVAMLTG SRGLRYATVI ALVAALVGGV YVLSSTGNKR TIVGYFTSAV GLYPGDQVRV 61 LGVPVGEIDM IEPRSSDVKI TMSVSKDVKV PVDVQAVIMS PNLVAARFIQ LTPVYTGGAV 121 LPDNGRIDLD RTAVPVEWDE VKEGLTRLAA DLSPAAGELQ GPLGAAINQA ADTLDGNGDS 181 LHNALRELAQ VAGRLGDSRG DIFGTVKNLQ VLVDALSESD EQIVQFAGHV ASVSQVLADS 241 SANLDQTLGT LNQALSDIRG FLRENNSTLI ETVNQLNDFA QTLSDQSENI EQVLHVAGPG 301 ITNFYNIYDP AQGTLNGLLS IPNFANPVQF ICGGSFDTAA GPSAPDYYRR AEICRERLGP 361 VLRRLTVNYP PIMFHPLNTI TAYKGQIIYD TPATEAKSET PVPELTWVPA GGGAPVGNPA 421 DLQSLLVPPA PGPAPAPPAP GAGPGEHGGG G //