LOCUS CCP46317.1 384 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible Mce-family lipoprotein
LprN (Mce-family lipoprotein Mce4E) protein.
ACCESSION AL123456-3595
PROTEIN_ID CCP46317.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="lprN"
/gene_synonym="mce4E"
/locus_tag="Rv3495c"
/note="Rv3495c, (MTV023.02c), len: 384 aa. Possible lprN
(alternate gene name: mce4E), lipoprotein which belongs to
24-membered Mycobacterium tuberculosis Mce protein family
(see citations below), highly similar to Mycobacterium
tuberculosis proteins O07417|LPRK|Rv0173|MTCI28.13|mce1E
(390 aa); O07785|LPRL|Rv0593|MTCY19H5.29|mce2E (402 aa);
and O53971|LPRM|Rv1970|MTV051.08|mce3E (377 aa). Also
similar to others e.g. Q9F360|SC8A2.03c putative secreted
protein from Streptomyces coelicolor (413 aa), FASTA
scores: opt: 656, E(): 2.2e-32, (37.55% identity in 317 aa
overlap); Q9CD10|LPRK|ML2593 putative lipoprotein from
Mycobacterium leprae (392 aa), FASTA scores: opt: 616,
E(): 5.5e-30, (28.95% identity in 373 aa overlap); etc.
Contains possible signal sequence and appropriately
positioned PS00013 Prokaryotic membrane lipoprotein lipid
attachment site."
/db_xref="EnsemblGenomes-Gn:Rv3495c"
/db_xref="EnsemblGenomes-Tr:CCP46317"
/db_xref="GOA:I6Y3P1"
/db_xref="InterPro:IPR003399"
/db_xref="InterPro:IPR005693"
/db_xref="UniProtKB/Swiss-Prot:I6Y3P1"
/inference="protein motif:PROSITE:PS00013"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MNRIWLRAII LTASSALLAG CQFGGLNSLP LPGTAGHGEG AYSVTVEMAD VATLPQNSPV
61 MVDDVTVGSV AGIVAVQRPD GSFYAAVKLD LDKNVLLPAN AVAKVSQTSL LGSLHVELAP
121 PTDRPPTGRL VDGSRITEAN TDRFPTTEEV FSALGVVVNK GNVGALEEII DETHQAVAGR
181 QAQFVNLVPR LAELTAGLNR QVHDIIDALD GLNRVSAILA RDKDNLGRAL DTLPDAVRVL
241 NQNRDHIVDA FAALKRLTMV TSHVLAETKV DFGEDLKDLY SIVKALNDDR KDFVTSLQLL
301 LTFPFPNFGI KQAVRGDYLN VFTTFDLTLR RIGETFFTTA YFDPNMAHMD EILNPPDFLI
361 GELANLSGQA ADPFKIPPGT ASGQ
//