LOCUS CCP46233.1 529 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable inosine-5'-monophosphate
dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid
dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase)
(inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)
protein.
ACCESSION AL123456-3511
PROTEIN_ID CCP46233.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="guaB2"
/locus_tag="Rv3411c"
/note="Rv3411c, (MTCY78.17), len: 529 aa. Probable
guaB2,inosine-5'-monophosphate (imp) dehydrogenase,
equivalent to Q49729|IMDH_MYCLE|GUAB|ML0387|B1620_C3_238
inosine-5'-monophosphate dehydrogenase from Mycobacterium
leprae (529 aa), FASTA scores: opt: 3154, E():
4.4e-165,(92.45% identity in 529 aa overlap). Highly
similar to other inosine-5'-monophosphate dehydrogenases
e.g. Q9RHZ0|GUAB from Corynebacterium ammoniagenes
(Brevibacterium ammoniagenes) (506 aa), FASTA scores: opt:
2284, E(): 1.5e-117, (67.9% identity in 505 aa overlap);
Q9L0I7|SCD63.02 from Streptomyces coelicolor (501
aa),FASTA scores: opt: 2178, E(): 9e-112, (67.2% identity
in 491 aa overlap); O67820|IMDH_AQUAE|GUAB|AQ_2023 from
Aquifex aeolicus (490 aa), FASTA scores: opt: 1820, E():
3.2e-92, (58.1% identity in 487 aa overlap); etc. Also
similar to Q50716|YY10_MYCTU|Rv3410c|MT3518|MTCY78.18
hypothetical 38.9 KDA protein from Mycobacterium
tuberculosis (38.6% identity in 158 aa overlap). Contains
PS00487 imp dehydrogenase / GMP reductase signature.
Similar to other eukaryotic and prokaryotic IMPDH and to
GMP reductase."
/db_xref="EnsemblGenomes-Gn:Rv3411c"
/db_xref="EnsemblGenomes-Tr:CCP46233"
/db_xref="GOA:P9WKI7"
/db_xref="InterPro:IPR000644"
/db_xref="InterPro:IPR001093"
/db_xref="InterPro:IPR005990"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR015875"
/db_xref="PDB:4ZQM"
/db_xref="PDB:4ZQN"
/db_xref="PDB:4ZQO"
/db_xref="PDB:4ZQP"
/db_xref="PDB:4ZQR"
/db_xref="PDB:5UPU"
/db_xref="PDB:5UPV"
/db_xref="UniProtKB/Swiss-Prot:P9WKI7"
/inference="protein motif:PROSITE:PS00487"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSRGMSGLED SSDLVVSPYV RMGGLTTDPV PTGGDDPHKV AMLGLTFDDV LLLPAASDVV
61 PATADTSSQL TKKIRLKVPL VSSAMDTVTE SRMAIAMARA GGMGVLHRNL PVAEQAGQVE
121 MVKRSEAGMV TDPVTCRPDN TLAQVDALCA RFRISGLPVV DDDGALVGII TNRDMRFEVD
181 QSKQVAEVMT KAPLITAQEG VSASAALGLL RRNKIEKLPV VDGRGRLTGL ITVKDFVKTE
241 QHPLATKDSD GRLLVGAAVG VGGDAWVRAM MLVDAGVDVL VVDTAHAHNR LVLDMVGKLK
301 SEVGDRVEVV GGNVATRSAA AALVDAGADA VKVGVGPGSI CTTRVVAGVG APQITAILEA
361 VAACRPAGVP VIADGGLQYS GDIAKALAAG ASTAMLGSLL AGTAEAPGEL IFVNGKQYKS
421 YRGMGSLGAM RGRGGATSYS KDRYFADDAL SEDKLVPEGI EGRVPFRGPL SSVIHQLTGG
481 LRAAMGYTGS PTIEVLQQAQ FVRITPAGLK ESHPHDVAMT VEAPNYYAR
//