LOCUS CCP46124.1 389 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible N-acyl-L-amino
acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase)
protein.
ACCESSION AL123456-3402
PROTEIN_ID CCP46124.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="amiA1"
/gene_synonym="amiA"
/locus_tag="Rv3305c"
/note="Rv3305c, (MTV016.04c), len: 389 aa. Possible
amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase),
similar to many proteins e.g. Q9AK43|2SCK8.09 putative
peptidase from Streptomyces coelicolor (410 aa), FASTA
scores: opt: 1015, E(): 3.9e-54, (50.8% identity in 374 aa
overlap); Q9UZ30|PAB0873 amino acid amidohydrolase from
Pyrococcus abyssi (383 aa), FASTA scores: opt: 823, E():
1.6e-42,(38.2% identity in 369 aa overlap); O58453|PH0722
long hypothetical amino acid amidohydrolase from
Pyrococcus horikoshii (388 aa), FASTA scores: opt: 815,
E(): 4.8e-42,(38.75% identity in 369 aa overlap);
O34980|YTNL_BACSU hypothetical 45.2 KDA protein from B.
subtilis (416 aa),FASTA scores: opt: 805, E(): 2.1e-41,
(37.85% identity in 367 aa overlap); Q9KCF8|BH1613
N-acyl-L-amino acid amidohydrolase from Bacillus
halodurans (404 aa), FASTA scores: opt: 795, E(): 8.1e-41,
(37.7% identity in 382 aa overlap); BAB50445|MLR3583
hypothetical hippurate hydrolase from Rhizobium loti
(Mesorhizobium loti) (387 aa), FASTA scores: opt: 761,
E(): 8.9e-39, (37.65% identity in 385 aa overlap);
Q9RXH4|DR0339 putative N-acyl-L-amino acid amidohydrolase
from Deinococcus radiodurans (392 aa), FASTA scores: opt:
745, E(): 8.4e-38, (36.15% identity in 379 aa overlap);
etc. Contains PS00639 Eukaryotic thiol (cysteine)
proteases histidine active site. Note that previously
known as amiA."
/db_xref="EnsemblGenomes-Gn:Rv3305c"
/db_xref="EnsemblGenomes-Tr:CCP46124"
/db_xref="GOA:L7N663"
/db_xref="InterPro:IPR002933"
/db_xref="InterPro:IPR017439"
/db_xref="InterPro:IPR036264"
/db_xref="UniProtKB/TrEMBL:L7N663"
/inference="protein motif:PROSITE:PS00639"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSLADAAESW LAAHHDDLVG WRRHIHRYPE LGRQEYATTQ FVAERLADAG LNPKVLPGGT
61 GLTCDFGPQH QPRIALRADM DALPMAERTG APYASTMPNV AHACGHDAHT AILLGAALAL
121 ASVPELPVGV RLIFQAAEEL MPGGAIDAIA AGALAGVSRI FALHCDPRLE VGKVAVRQGP
181 ITSAADSIEI TLYSPGGHTS RPHLTADLVY GLGTLVTGLP GVLSRRIDPR NSTVLVWGAV
241 NAGMAANAIP QTGVLSGTVR TASRQTWVDL EELVRQAISA LLLPLAIEHT LQYRRGVPPV
301 VNEEISTRIL AHAIEAIGPG VLADTRQSGG GEDFSWYLEE VPGAMARLGV WSGDGLQLDL
361 HQPTFDIDER ALAIGLRVMV NIIEQAAAH
//