LOCUS CCP46115.1 1513 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable ATP-dependent
helicase Lhr (large helicase-related protein) protein.
ACCESSION AL123456-3393
PROTEIN_ID CCP46115.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="lhr"
/locus_tag="Rv3296"
/note="Rv3296, (MTCY71.36), len: 1513 aa. Probable
lhr,ATP-dependent helicase, similar to others e.g.
P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain
K12 (1538 aa), FASTA scores: opt: 2930, E(): 1.5e-159,
(47.55% identity in 1569 aa overlap); AAG56642|LHR from
Escherichia coli stain O157:H7 EDL933 (1538 aa), FASTA
scores: opt: 2930, E(): 1.5e-159, (47.6% identity in 1561
aa overlap); O86821|SC7C7.16c from Streptomyces coelicolor
(1690 aa),FASTA scores: opt: 2919, E(): 7e-159, (53.55%
identity in 1703 aa overlap); Q9HYW9|PA3272 from
Pseudomonas aeruginosa (1448 aa), FASTA scores: opt: 907,
E(): 6.2e-44, (35.85% identity in 1512 aa overlap); etc.
Similar to dead/DEAH box helicase family and to helicase
C-terminal domain. Contains PS00017 ATP/GTP-binding site
motif A and possible helix-turn-helix motif."
/db_xref="EnsemblGenomes-Gn:Rv3296"
/db_xref="EnsemblGenomes-Tr:CCP46115"
/db_xref="GOA:P96901"
/db_xref="InterPro:IPR001650"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR011545"
/db_xref="InterPro:IPR013701"
/db_xref="InterPro:IPR014001"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/TrEMBL:P96901"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MRFAQPSALS RFSALTRDWF TSTFAAPTAA QASAWAAIAD GDNTLVIAPT GSGKTLAAFL
61 WALDSLAGSE PMSERPAATR VLYVSPLKAL AVDVERNLRT PLAGLTRLAE RQGLPAPQIR
121 VGVRSGDTPP ALRRQLVSQP PDVLITTPES LFLMLTSAAR QTLTGVQTVI IDEIHAIAAT
181 KRGAHLALSL ERLDDLSSRR RAQRIGLSAT VRPPEELARF LSGQSPTTIV APPAAKTVEL
241 SVQVPVPDMA NLTDNTIWPD VEARLVDLIE SHNSTIVFAN SRRLAERLTA RLNEIHAARC
301 GIELAPDTNQ QVAGGAPAHI MGSGQTFGAP PVLARAHHGS ISKEQRAVVE EDLKRGQLKA
361 VVATSSLELG IDMGAVDLVI QVQAPPSVAS GLQRIGRAGH QVGEISRGVL FPKHRTDLLG
421 CAVSVQRMLA GEIETMRVPA NPLDILAQHT VAAAALEPLD ADAWFDTVRR AAPFATLPRS
481 LFEATLDLLS GKYPSTEFAE LRPRLVYDRD TGTLTARPGA QRLAVTSGGA IPDRGLFAVY
541 LATERPSRVG ELDEEMVYES RPGDVISLGA TSWRITEITH DRVLVIPAPG QPARLPFWRG
601 DDAGRPAELG AALGALTGEL AALDRTAFGT RCAGLGFDDY ATDNLWRLLD DQRTATAVVP
661 TDSTLLVERF RDELGDWRVI LHSPYGLRVH GPLALAVGRR LRDRYGIDEK PTASDNGIVV
721 RLPDTVSAGE DSPPGAELFV FDADEIDPIV TTEVAGSALF ASRFRESAAR ALLLPRRHPG
781 RRSPLWQQRQ RAARLLEVAR KYPDFPIVLE TVRECLQDVY DVPILVELMA RIAQRRVRVA
841 EAETAKPSPF AASLLFGYVG AFMYEGDTPL AERRAAALAL DGTLLAELLG RVELRELLDP
901 DVIAATSRQL QHLAADRVAR DAEGVADLLR LLGPLTEDEI AARAGAPEVS GWLDGLRAAK
961 RALVVSFAGR SWWVAVEDMG RLRDGVGAAV PVGLPASFTE AVADPLGELL GRYARTHTPF
1021 TTAAAAARFG LGLRVTADVL GRLASDGRLV RGEFVAAAKG SAGGEQWCDA EVLRILRRRS
1081 LAALRAQAEP VSTAAYGRFL PAWQHVSAGN SGIDGLAAVI DQLAGVRIPA SAIEPLVLAP
1141 RIRDYSPAML DELLASGDVT WSGAGSISGS DGWIALHPAD SAPMTLAEPA EIDFTDAHRA
1201 ILASLGTGGA YFFRQLTHDG LTEAELKAAL WELIWAGRVT GDTFAPVRAV LGGAGTRKRA
1261 APAHGGHRPP RLSRYRLTHA QARNADPTVA GRWSALPLPE PDSTLRAHYQ AELLLNRHGV
1321 LTKDAVAAEG VAGGFATLYK VLSAFEDAGR CQRGYFIESL GGAQFAVAST VDRLRSYLDG
1381 VDPEQPDYHA VVLAAADPAN PYGAALPWPA SSADGTARPG RKAGALVVLV DGELAWFLER
1441 GGRSLLTFTD DPEANHAAAI GLADLVTAGR VASILVERAD GMPVLQPGGR ASAALTALLA
1501 AGFVRTPRGL RRR
//