LOCUS CCP46112.1 494 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable piperideine-
6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate
dehydrogenase) protein.
ACCESSION AL123456-3390
PROTEIN_ID CCP46112.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pcd"
/gene_synonym="aldB"
/locus_tag="Rv3293"
/note="Rv3293, (MTCY71.33), len: 494 aa. Probable
pcd,piperideine-6-carboxylic acid dehydrogenase, highly
similar to others e.g. O85725|PCD semialdehyde
dehydrogenase from Streptomyces clavuligerus (512 aa),
FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity
in 496 aa overlap) (see Alexander & Jensen 1998);
Q9I4U7|PA1027 probable aldehyde dehydrogenase from
Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,
E(): 1.4e-107, (64.5% identity in 493 aa overlap);
BAB49892|MLL2867 aldehyde dehydrogenase from Rhizobium
loti (Mesorhizobium loti) (504 aa), FASTA scores: opt:
1964, E(): 2e-106, (62.8% identity in 476 aa overlap);
Q9A8Y1|CC1216 aldehyde dehydrogenase from Caulobacter
crescentus (507 aa), FASTA scores: opt: 1909, E():
3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD
piperideine-6-carboxilic acid dehydrogenase from
Streptomyces clavuligerus (496 aa), FASTA scores: opt:
1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap);
and Q9F1U8|PCD piperideine-6-carboxylate dehydrogenase
from 'Flavobacterium' lutescens (510 aa), FASTA scores:
opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa
overlap) (see Fujii et al., 2000); etc. Contains PS00687
Aldehyde dehydrogenases glutamic acid active site. Note
that ORF Rv3290c seems to encoded the putative lat enzyme.
Note that previously known as aldB."
/db_xref="EnsemblGenomes-Gn:Rv3293"
/db_xref="EnsemblGenomes-Tr:CCP46112"
/db_xref="GOA:L7N650"
/db_xref="InterPro:IPR015590"
/db_xref="InterPro:IPR016161"
/db_xref="InterPro:IPR016162"
/db_xref="InterPro:IPR016163"
/db_xref="InterPro:IPR029510"
/db_xref="UniProtKB/TrEMBL:L7N650"
/inference="protein motif:PROSITE:PS00687"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MLEACQAIGV TAALGEPGEH SLPASTPITG DVLFSIAPTT PEQADHAIAA AAATFTAWRS
61 TPAPVRGALV ARLGELLTAH QQDLATLVTV EVGKITAEAR GEVQEMIDVC QFSVGLSRQL
121 YGRTIASERA GHRLLETWHP LGVVGVITAF NFPVAVWAWN TAVALVCGDT VVWKPSELTP
181 LTALACQALL SRAAADVGAP AAVGGLLLGG AERGAQLVDD PRVALLSATG SVRMGQQVGP
241 RVARRFGRVL LELGGNNAAI VAPSADLELA VRGIVFAAAG TAGQRCTSLR RLIVHRSVAD
301 DVVARVVGAY RQLAIGDPSA PDTLVGPLIH EAAYRDMVAA LERARTDGGE VIGGDRREVG
361 SPGAYYVAPA VVRMPSQTAI VATETFAPIL YVLTYDDLDE AIALNNAVPQ GLSSSIFTTD
421 LREAEHFLDQ SDCGIANVNI GTSGAEIGGA FGGEKQTGGG RESGSDAWKA YMRRATNTVN
481 YSSELPLAQG VKFG
//