LOCUS CCP46092.1 764 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable transmembrane
carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
protein.
ACCESSION AL123456-3370
PROTEIN_ID CCP46092.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/locus_tag="Rv3273"
/note="Rv3273, (MTCY71.13), len: 764 aa. Probable
transmembrane protein (N-terminal part is hydrophobic)
with probable carbonic anhydrase activity (in C-terminal
part). Possibly involved in transport of sulfate.
Equivalent to Q9CBA3|ML2279 putative transmembrane
transport protein from Mycobacterium leprae (496 aa),
FASTA scores: opt: 1637,E(): 1.8e-89, (59.15% identity in
487 aa overlap). Similar to various proteins (principally
sulfate transporters) e.g. Q9X927|SCH5.25 putative
integral membrane protein from Streptomyces coelicolor
(830 aa), FASTA scores: opt: 1325,E(): 8e-71, (40.85%
identity in 788 aa overlap); Q9I729|PA0103 probable
sulfate transporter from Pseudomonas aeruginosa (523 aa),
FASTA scores: opt: 1015, E(): 1.3e-52,(39.95% identity in
488 aa overlap); Q9KN88|VCA0077 sulfate permease family
protein from Vibrio cholerae (553 aa),FASTA scores: opt:
629, E(): 9.6e-30, (30.95% identity in 423 aa overlap);
etc. C-terminal part (aa 550-764) shows similarity to
carbonic anhydrase e.g. P27134|CYNT_SYNP7 carbonic
anhydrase (272 aa), FASTA scores: opt: 350, E(): 8.1e-15,
(33.8% identity in 201 aa overlap). Contains PS00704
Prokaryotic-type carbonic anhydrases signature 1. Seems to
belong to the SulP family."
/db_xref="EnsemblGenomes-Gn:Rv3273"
/db_xref="EnsemblGenomes-Tr:CCP46092"
/db_xref="GOA:P96878"
/db_xref="InterPro:IPR001765"
/db_xref="InterPro:IPR001902"
/db_xref="InterPro:IPR011547"
/db_xref="InterPro:IPR015892"
/db_xref="InterPro:IPR036874"
/db_xref="UniProtKB/TrEMBL:P96878"
/inference="protein motif:PROSITE:PS00704"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MTIPRSQHMS TAVNSCTEAP ASRSQWMLAN LRHDVPASLV VFLVALPLSL GIAIASGAPI
61 IAGVIAAVVG GIVAGAVGGS PVQVSGPAAG LTVVVAELID ELGWPMLCLM TIAAGALQIV
121 FGLSRMARAA LAIAPVVVHA MLAGIGITIA LQQIHVLLGG TSHSSAWRNI VALPDGILHH
181 ELHEVIVGGT VIAILLMWSK LPAKVRIIPG PLVAIAGATV LALLPVLQTE RIDLQGNFFD
241 AIGLPKLAEM SPGGQPWSHE ISAIALGVLT IALIASVESL LSAVGVDKLH HGPRTDFNRE
301 MVGQGSANVV SGLLGGLPIT GVIVRSSANV AAGARTRMST ILHGVWILLF ASLFTNLVEL
361 IPKAALAGLL IVIGAQLVKL AHIKLAWRTG NFVIYAITIV CVVFLNLLEG VAIGLVVAIV
421 FLLVRVVRAP VEVKPVGGEQ SKRWRVDIDG TLSFLLLPRL TTVLSKLPEG SEVTLNLNAD
481 YIDDSVSEAI SDWRRAHETR GGVVAIVETS PAKLHHAHAR PPKRHFASDP IGLVPWRSAR
541 GKDRGSASVL DRIDEYHRNG AAVLHPHIAG LTDSQDPYEL FLTCADSRIL PNVITASGPG
601 DLYTVRNLGN LVPTDPDDRS VDAALDFAVN QLGVSSVVVC GHSSCAAMTA LLEDDPANTT
661 TPMMRWLENA HDSLVVFRNH HPARRSAESA GYPEADQLSI VNVAVQVERL TRHPILATAV
721 AAADLQVIGI FFDISTARVY EVGPNGIICP DEPADRPVDH ESAQ
//