LOCUS CCP46067.1 495 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable adenosylhomocysteinase
SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)
protein.
ACCESSION AL123456-3345
PROTEIN_ID CCP46067.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="sahH"
/locus_tag="Rv3248c"
/note="Rv3248c, (MTCY20B11.23c), len: 495 aa. Probable
sahH, adenosylhomocysteinase, equivalent to
Q9CCJ4|SAHH|ML0771 putative S-adenosyl-L-homocysteine
hydrolase from Mycobacterium leprae (492 aa), FASTA
scores: opt: 3019, E(): 1.3e-177, (91.4% identity in 489
aa overlap). Also highly similar to other
adenosylhomocysteinases e.g. Q9KZM1|SAHH from Streptomyces
coelicolor (485 aa), FASTA scores: opt: 2258, E():
5.7e-131, (70.0% identity in 483 aa overlap);
P51540|SAHH_TRIVA from Trichomonas vaginalis (486
aa),FASTA scores: opt: 2005, E(): 1.8e-115, (62.05%
identity in 477 aa overlap); P35007|SAHH_CATRO from
Catharanthus roseus (Rosy periwinkle) (Madagascar
periwinkle) (485 aa), FASTA scores: opt: 1941, E():
1.5e-111, (60.15% identity in 492 aa overlap); etc. Has
S-adenosyl-L-homocysteine hydrolase signature (PS00739).
Belongs to the adenosylhomocysteinase family."
/db_xref="EnsemblGenomes-Gn:Rv3248c"
/db_xref="EnsemblGenomes-Tr:CCP46067"
/db_xref="GOA:P9WGV3"
/db_xref="InterPro:IPR000043"
/db_xref="InterPro:IPR015878"
/db_xref="InterPro:IPR020082"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR042172"
/db_xref="PDB:2ZIZ"
/db_xref="PDB:2ZJ0"
/db_xref="PDB:2ZJ1"
/db_xref="PDB:3CE6"
/db_xref="PDB:3DHY"
/db_xref="UniProtKB/Swiss-Prot:P9WGV3"
/inference="protein motif:PROSITE:PS00739"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MTGNLVTKNS LTPDVRNGID FKIADLSLAD FGRKELRIAE HEMPGLMSLR REYAEVQPLK
61 GARISGSLHM TVQTAVLIET LTALGAEVRW ASCNIFSTQD HAAAAVVVGP HGTPDEPKGV
121 PVFAWKGETL EEYWWAAEQM LTWPDPDKPA NMILDDGGDA TMLVLRGMQY EKAGVVPPAE
181 EDDPAEWKVF LNLLRTRFET DKDKWTKIAE SVKGVTEETT TGVLRLYQFA AAGDLAFPAI
241 NVNDSVTKSK FDNKYGTRHS LIDGINRGTD ALIGGKKVLI CGYGDVGKGC AEAMKGQGAR
301 VSVTEIDPIN ALQAMMEGFD VVTVEEAIGD ADIVVTATGN KDIIMLEHIK AMKDHAILGN
361 IGHFDNEIDM AGLERSGATR VNVKPQVDLW TFGDTGRSII VLSEGRLLNL GNATGHPSFV
421 MSNSFANQTI AQIELWTKND EYDNEVYRLP KHLDEKVARI HVEALGGHLT KLTKEQAEYL
481 GVDVEGPYKP DHYRY
//