LOCUS CCP46058.1 1048 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable conserved transmembrane
transport protein protein.
ACCESSION AL123456-3336
PROTEIN_ID CCP46058.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/locus_tag="Rv3239c"
/note="Rv3239c, (MTCY20B11.14c), len: 1048 aa. Probable
conserved transmembrane protein, organised in two domains.
Domain comprising first ~500 aa residues is similar to
various antibiotic resistance and efflux proteins and
contains sugar transport proteins signature 1 (PS00216);
e.g. Q9RL22|SC5G9.04c putative transmembrane efflux
protein from Streptomyces coelicolor (489 aa), FASTA
scores: opt: 905, E(): 3.1e-41, (36.95% identity in 482 aa
overlap); and O68912|FRNF putative antibiotic antiporter
from Streptomyces roseofulvus (517 aa), FASTA scores: opt:
866,E(): 4.1e-39, (37.1% identity in 512 aa overlap).
Second part, corresponding to last 550 aa residues, is
very similar to Q50733|Rv2565|MTCY9C4.03c hypothetical
62.1 kDa protein from Mycobacterium tuberculosis (583 aa),
FASTA scores: E(): 2.1e-28, (36.5% identity in 572 aa
overlap). Also equivalent to Rv3728|MTV025.076 putative
two-domain membrane protein (similar to sugar transporter
family) from Mycobacterium tuberculosis (1065 aa), FASTA
scores: opt: 4328, E(): 0, (64.15% identity in 1046 aa
overlap); and similar to other Mycobacterium tuberculosis
proteins: MTCY3G12.01, E(): 6.3e-32; MTCY98.02c, E():
6.3e-32; MTCY9C4.03c, E(): 1.5e-26; MTCY369.27c, E():
2.5e-26. Equivalent to AAK47679 Drug transporter from
Mycobacterium tuberculosis strain CDC1551 (1065 aa) but
shorter 20 aa. Contains cyclic nucleotide-binding domain
signature 2 (PS00889). Probably member of major
facilitator superfamily (MFS)."
/db_xref="EnsemblGenomes-Gn:Rv3239c"
/db_xref="EnsemblGenomes-Tr:CCP46058"
/db_xref="GOA:O05884"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR004638"
/db_xref="InterPro:IPR005829"
/db_xref="InterPro:IPR011701"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR020846"
/db_xref="InterPro:IPR036259"
/db_xref="UniProtKB/TrEMBL:O05884"
/inference="protein motif:PROSITE:PS00889"
/inference="protein motif:PROSITE:PS00216"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MHISLHGGKG FANLTRRRRP SSASVLLVAG FGAFLAFLDS TIVNIAFPDI QRSFPSYDIG
61 SLSWILNGYN IVFAAFMVAA GRLADLLGRR RTFLSGVLVF TIASGLCAVA GSVEQLVAFR
121 VLQGIGAAIL VPASLALVVE GFDAARRAHA IGLWGAAAAI AAGLGPPIGG LLVEWAGWRW
181 VLLVNVPLGI VAAIATKRML VESRASGRRR MPDLRGALLL AVTLGLVTLG LVKGPDWGWL
241 SVATVGSFLA SVLTSVGFVH SSRSHPAPLV EPALLRSRSF VAGNLLTLVA AAGFYCYGLT
301 HVLYLNYVWH YSLLKAGFAI APAAVVAAVV AAALGRVAGR HGHRVIVLVG ALVWAGSLVW
361 YLQRVGSEPD FLRVWLPGQL LQGIGVGATL PVLSSAALAE VAKGGSYATS SAVVSTTRQL
421 GAVLGVAVMV ILIGKPEHGT AEEALRRGWA MAAICFIAVA VAAAVLGRTN RNPVQMPAPE
481 PAIAPRLEPP IPQPAAAPIE HWAAGDADPL GNLPLFAGLD AATLAQLGEH VEDVELEAGC
541 YLFHEGDPSD SLYVIRTGRV QVLQDSIVLK ELGRGEVLGE LGLLIDAPRS ATVRALRDTK
601 LVRLTKAQFD EIADHGALAA LVKVLATRLR EAPPPATDST SPEVVVSVIG VSGDAPVPAV
661 AAGLLTALSA RLRAVDPGRV DRDGLDRAER VADKVVLHAA VEDAGWRDFC LRVADRIVLV
721 AGDPNPQAAR LPARARGADL VLAGPAASRE HRRQWEELIT PRSVHVVHYR RILENVRPLA
781 ARIAGRSIGL VLGGGGARGF AHLGVLDELE RVGVTIDRFA GTSMGAVIAV FGACGMDAAT
841 ADAYAYEYFI RHNPLSDYAF PVRGLVRGRR TLTLLEAAFG DRLVEELPKE FRCVSVDLLA
901 RRPVVHRRGR LVDVIGCSLR LPGIYPPQVY NGRLHVDGGV LDNLPVSTRA SPDGPLIAVS
961 IGLGGGGPGS ARQDGSPKVP GIGDTLMRTM TIGSQRGADA ALSLAQVVIR PDTGAVGLLE
1021 FHQIDAAREA GRVAAREAMP HIMALLNR
//