LOCUS CCP46041.1 282 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible iron-regulated
short-chain dehydrogenase/reductase protein.
ACCESSION AL123456-3319
PROTEIN_ID CCP46041.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/locus_tag="Rv3224"
/note="Rv3224, (MTCY07D11.02c), len: 282 aa. Probable
iron-regulated oxidoreductase, possible short-chain
dehydrogenase/reductase, highly similar to
BAB49551|MLL2413 hypothetical protein from Rhizobium loti
(Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053,
E(): 6.4e-59,(57.95% identity in 276 aa overlap);
Q9AB34|CC0400 short chain dehydrogenase family protein
from Caulobacter crescentus (285 aa), FASTA scores: opt:
1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and
Q9VB10|CG5590 hypothetical protein (similar to the
short-chain dehydrogenases/reductases (SDR) family) from
Drosophila melanogaster (Fruit fly) (412 aa), FASTA
scores: opt: 966,E(): 2.5e-53, (52.15% identity in 278 aa
overlap). Similar to various proteins (principaly
oxidoreductases) e.g. Q18639|C45B11.3 hypothetical protein
(similar to the SDR family) from Caenorhabditis elegans
(293 aa), FASTA scores: opt: 921, E(): 1.2e-50, (51.3%
identity in 271 aa overlap); Q9HZV5|PA2892 probable
short-chain dehydrogenase from Pseudomonas aeruginosa (274
aa), FASTA scores: opt: 847,E(): 5.1e-46, (49.25% identity
in 274 aa overlap); Q9I6V0|PA0182 probable short-chain
dehydrogenase (similar to the SDR family) from Pseudomonas
aeruginosa (250 aa),FASTA scores: opt: 333, E(): 8.3e-14,
(29.8% identity in 245 aa overlap); Q9HY98|PA3511 probable
short-chain dehydrogenase from Pseudomonas aeruginosa (253
aa), FASTA scores: opt: 330, E(): 1.3e-13, (31.2% identity
in 250 aa overlap); etc. Related proteins in Mycobacterium
tuberculosis include MTCY02B10.14, MTCY369.14, and
MTCY09F9.36. Has ATP/GTP-binding site motif A, (PS00017)
near C-terminus. May be belong to the short-chain
dehydrogenases/reductases (SDR) family."
/db_xref="EnsemblGenomes-Gn:Rv3224"
/db_xref="EnsemblGenomes-Tr:CCP46041"
/db_xref="GOA:O05842"
/db_xref="InterPro:IPR002347"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/TrEMBL:O05842"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSLNGKTMFI SGASRGIGLA IAKRAARDGA NIALIAKTAE PHPKLPGTVF TAAKELEEAG
61 GQALPIVGDI RDPDAVASAV ATTVEQFGGI DICVNNASAI NLGSITEVPM KRFDLMNGIQ
121 VRGTYAVSQA CIPHMKGREN PHILTLSPPI LLEKKWLRPT AYMMAKYGMT LCALGIAEEM
181 RADGIASNTL WPRTMVATAA VQNLLGGDEA MARSRKPEVY ADAAYVIVNK PATEYTGKTL
241 LCEDVLVESG VTDLSVYDCV PGATLGVDLW VEDANPPGYL PA
//