LOCUS CCP46021.1 392 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable molybdenum cofactor
biosynthesis protein MoeB1 (MPT-synthase sulfurylase)
(molybdopterin synthase sulphurylase) protein.
ACCESSION AL123456-3299
PROTEIN_ID CCP46021.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="moeB1"
/gene_synonym="moeZ"
/locus_tag="Rv3206c"
/note="Rv3206c, (MTCY07D11.20), len: 392 aa. Probable
moeB1, molybdopterin cofactor biosynthesis
protein,equivalent to Q9CCG8|MOEZ|ML0817 protein probably
involved in molybdopterin biosynthesis from Mycobacterium
leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130,
(86.45% identity in 391 aa overlap.) Very similar to
members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02
putative sulfurylase from Streptomyces coelicolor (392
aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3%
identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-like
protein (putative sulfurylase) from Pseudomonas stutzeri
(Pseudomonas perfectomarina) (391 aa), FASTA scores: opt:
1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap);
O54307|MPT|MOEB MPT-synthase sulfurylase from
Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
(391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95%
identity in 387 aa overlap); P74344|MOEB|SLL1536
molybdopterin biosynthesis MOEB protein from Synechocystis
sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308,
E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also
highly similar to O05792|MOEB2|Rv3116|MTCY164.26 putative
molybdenum cofactor biosynthesis protein from
Mycobacterium tuberculosis (389 aa), FASTA scores: opt:
1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap).
Has hydrophobic segment from ~45-71. Belongs to the
HesA/MoeB/ThiF FAMILY. Note that previously known as moeZ.
Thought to be differentially expressed within host cells
(see citation below)."
/db_xref="EnsemblGenomes-Gn:Rv3206c"
/db_xref="EnsemblGenomes-Tr:CCP46021"
/db_xref="GOA:P9WMN7"
/db_xref="InterPro:IPR000594"
/db_xref="InterPro:IPR001763"
/db_xref="InterPro:IPR035985"
/db_xref="InterPro:IPR036873"
/db_xref="UniProtKB/Swiss-Prot:P9WMN7"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSTSLPPLVE PASALSREEV ARYSRHLIIP DLGVDGQKRL KNARVLVIGA GGLGAPTLLY
61 LAAAGVGTIG IVDFDVVDES NLQRQVIHGV ADVGRSKAQS ARDSIVAINP LIRVRLHELR
121 LAPSNAVDLF KQYDLILDGT DNFATRYLVN DAAVLAGKPY VWGSIYRFEG QASVFWEDAP
181 DGLGVNYRDL YPEPPPPGMV PSCAEGGVLG IICASVASVM GTEAIKLITG IGETLLGRLL
241 VYDALEMSYR TITIRKDPST PKITELVDYE QFCGVVADDA AQAAKGSTIT PRELRDWLDS
301 GRKLALIDVR DPVEWDIVHI DGAQLIPKSL INSGEGLAKL PQDRTAVLYC KTGVRSAEAL
361 AAVKKAGFSD AVHLQGGIVA WAKQMQPDMV MY
//