LOCUS CCP45871.1 507 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable ATP-dependent
DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]
) (polynucleotide ligase [ATP]) (sealase) (DNA repair
protein) (DNA joinase) protein.
ACCESSION AL123456-3149
PROTEIN_ID CCP45871.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="ligB"
/locus_tag="Rv3062"
/note="Rv3062, (MTCY22D7.19c), len: 507 aa. Probable
ligB,DNA ligase ATP-dependent (see citation below), highly
similar to numerous archaebacterial and eukaryotic
polynucleotide DNA ligases, e.g.
Q9FCB1|DNLI_STRCO|LIG|2SCG58.02 from Streptomyces
coelicolor (512 aa), FASTA scores: opt: 1677, E():
2.5e-90,(55.65% identity in 512 aa overlap);
Q9HR35|DNLI_HALN1|LIG|VNG0881G from Halobacterium sp.
strain NRC-1 (561 aa), FASTA scores: opt: 985, E():
5.6e-50, (42.25% identity in 440 aa overlap);
Q9V185|DNLI_PYRAB|LIG|PAB2002 from Pyrococcus abyssi (559
aa), FASTA scores: opt: 978, E(): 1.4e-49, (39.05%
identity in 443 aa overlap); etc. Also similar to
Rv3731|MTV025.079|LIGC possible DNA ligase from M.
tuberculosis (358 aa). Similarity at N-terminus is poor so
first start codon was taken. Contains (PS00697)
ATP-dependent DNA ligase AMP-binding site signature, and
(PS00017) ATP/GTP-binding site motif A (P-loop). Belongs
to the ATP-dependent DNA ligase family."
/db_xref="EnsemblGenomes-Gn:Rv3062"
/db_xref="EnsemblGenomes-Tr:CCP45871"
/db_xref="GOA:P9WNV5"
/db_xref="InterPro:IPR000977"
/db_xref="InterPro:IPR012308"
/db_xref="InterPro:IPR012309"
/db_xref="InterPro:IPR012310"
/db_xref="InterPro:IPR012340"
/db_xref="InterPro:IPR016059"
/db_xref="InterPro:IPR022865"
/db_xref="InterPro:IPR036599"
/db_xref="UniProtKB/Swiss-Prot:P9WNV5"
/inference="protein motif:PROSITE:PS00697"
/inference="protein motif:PROSITE:PS00017"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MLLHDVAITS MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE LPQRHIGVGW
61 AALRSLPPPA PQPALTVTGV DATLSKIGTL PGKGSQAQRA ALVAELFSAA TEAEQTFLLR
121 LLGGELRQGA KGGIMADAVA QAAGLPAATV QRAAMLGGDL AAAAAAGLSG AALDTFTLRV
181 GRPIGPMLAQ TATSVHDALE RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL
241 PEVVEATLAL PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF
301 DILHRDGTDL LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT LAAGHEGVMA
361 KAPAARYLAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR GKLSNIHLGA RDPATGGFVM
421 VGKTFKGMTD AMLDWQTTRF HEIAVGPTDG YVVQLRPEQV VEVALDGVQR SSRYPGGLAL
481 RFARVVRYRA DKDPAEADTI DAVRALY
//