LOCUS CCP45771.1 1127 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable pyruvate carboxylase
Pca (pyruvic carboxylase) protein.
ACCESSION AL123456-3049
PROTEIN_ID CCP45771.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pca"
/locus_tag="Rv2967c"
/note="Rv2967c, (MTCY349.20), len: 1127 aa. Probable
pca,pyruvate carboxylase (ala-rich protein), equivalent to
Q9F843|PYC pyruvate carboxylase from Mycobacterium
smegmatis (1127 aa), FASTA scores: opt: 6232, E():
0,(83.3% identity in 1127 aa overlap). Also highly similar
to others e.g. Q9RK64|SCF11.26c pyruvate carboxylase from
Streptomyces coelicolor (1124 aa), FASTA scores: opt:
5526,E(): 0, (74.65% identity in 1125 aa overlap);
O54587|PYC pyruvate carboxylase from Corynebacterium
glutamicum (Brevibacterium flavum) (1140 aa), FASTA
scores: opt: 4811,E(): 0, (64.5% identity in 1132 aa
overlap); Q9DDT1 pyruvate carboxylase from Brachydanio
rerio (Zebrafish) (1180 aa), FASTA scores: opt: 3133, E():
1.1e-171, (47.8% identity in 1142 aa overlap); etc.
Contains PS00867 Carbamoyl-phosphate synthase subdomain
signature 2, PS00165 Serine/threonine dehydratases
pyridoxal-phosphate attachment site, and PS00188
Biotin-requiring enzymes attachment site."
/db_xref="EnsemblGenomes-Gn:Rv2967c"
/db_xref="EnsemblGenomes-Tr:CCP45771"
/db_xref="GOA:I6YEU0"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR000891"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR003379"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR005930"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/TrEMBL:I6YEU0"
/inference="protein motif:PROSITE:PS00188"
/inference="protein motif:PROSITE:PS00165"
/inference="protein motif:PROSITE:PS00867"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MFSKVLVANR GEIAIRAFRA AYELGVGTVA VYPYEDRNSQ HRLKADESYQ IGDIGHPVHA
61 YLSVDEIVAT ARRAGADAIY PGYGFLSENP DLAAACAAAG ISFVGPSAEV LELAGNKSRA
121 IAAAREAGLP VLMSSAPSAS VDELLSVAAG MPFPLFVKAV AGGGGRGMRR VGDIAALPEA
181 IEAASREAES AFGDPTVYLE QAVINPRHIE VQILADNLGD VIHLYERDCS VQRRHQKVIE
241 LAPAPHLDAE LRYKMCVDAV AFARHIGYSC AGTVEFLLDE RGEYVFIEMN PRVQVEHTVT
301 EEITDVDLVA SQLRIAAGET LEQLGLRQED IAPHGAALQC RITTEDPANG FRPDTGRISA
361 LRTAGGAGVR LDGSTNLGAE ISPYFDSMLV KLTCRGRDLP TAVSRARRAI AEFRIRGVST
421 NIPFLQAVLD DPDFRAGRVT TSFIDERPQL LTARASADRG TKILNFLADV TVNNPYGSRP
481 STIYPDDKLP DLDLRAAPPA GSKQRLVKLG PEGFARWLRE SAAVGVTDTT FRDAHQSLLA
541 TRVRTSGLSR VAPYLARTMP QLLSVECWGG ATYDVALRFL KEDPWERLAT LRAAMPNICL
601 QMLLRGRNTV GYTPYPEIVT SAFVQEATAT GIDIFRIFDA LNNIESMRPA IDAVRETGSA
661 IAEVAMCYTG DLTDPGEQLY TLDYYLKLAE QIVDAGAHVL AIKDMAGLLR PPAAQRLVSA
721 LRSRFDLPVH LHTHDTPGGQ LASYVAAWHA GADAVDGAAA PLAGTTSQPA LSSIVAAAAH
781 TEYDTGLSLS AVCALEPYWE ALRKVYAPFE SGLPGPTGRV YHHEIPGGQL SNLRQQAIAL
841 GLGDRFEEIE EAYAGADRVL GRLVKVTPTS KVVGDLALAL VGAGVSADEF ASDPARFGIP
901 ESVLGFLRGE LGDPPGGWPE PLRTAALAGR GAARPTAQLA ADDEIALSSV GAKRQATLNR
961 LLFPSPTKEF NEHREAYGDT SQLSANQFFY GLRQGEEHRV KLERGVELLI GLEAISEPDE
1021 RGMRTVMCIL NGQLRPVLVR DRSIASAVPA AEKADRGNPG HIAAPFAGVV TVGVCVGERV
1081 GAGQTIATIE AMKMEAPITA PVAGTVERVA VSDTAQVEGG DLLVVVS
//