LOCUS CCP45750.1 1616 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable polyketide synthase
Pks1 protein.
ACCESSION AL123456-3028
PROTEIN_ID CCP45750.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pks1"
/locus_tag="Rv2946c"
/note="Rv2946c, (MTCY24G1.03), len: 1616 aa. Probable
pks1,polyketide synthase, similar to many e.g.
ML035|AL583917|Q9CD81 putative polyketide synthase from
Mycobacterium leprae (2103 aa), Fasta scores: opt:
8761,E(): 0, (82.6% identity in 1620 aa overlap); etc.
Almost identical in part to G560507|Q50470 PKS002C protein
from Mycobacterium tuberculosis (fragment) (950 aa), Fasta
scores: opt: 5685, E(): 0, (95.3% identity in 927 aa
overlap). Also similar to Mycobacterium tuberculosis
polyketide synthases pks7|Rv1661|P94996 (2126 aa) (54.6%
identity in 1632 aa); pks12|Rv2048c|O53490 (4151 aa)
(58.0% identity in 1606 aa); pks8|rv1662|O65933 (1602 aa)
(59.7% identity in 1144 aa). Contains a PS00012
Phosphopantetheine attachment site. Note pks1 has been
shown to be involved in the biosynthesis of phthiocerol.
pks15/pks1 has been shown to be involved in the
biosynthesis of phenolphthiocerol glycolipids."
/db_xref="EnsemblGenomes-Gn:Rv2946c"
/db_xref="EnsemblGenomes-Tr:CCP45750"
/db_xref="GOA:P96285"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/Swiss-Prot:P96285"
/inference="protein motif:PROSITE:PS00012"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MISARSAEAL TAQAGRLMAH VQANPGLDPI DVGCSLASRS VFEHRAVVVG ASREQLIAGL
61 AGLAAGEPGA GVAVGQPGSV GKTVVVFPGQ GAQRIGMGRE LYGELPVFAQ AFDAVADELD
121 RHLRLPLRDV IWGADADLLD STEFAQPALF AVEVASFAVL RDWGVLPDFV MGHSVGELAA
181 AHAAGVLTLA DAAMLVVARG RLMQALPAGG AMVAVAASED EVEPLLGEGV GIAAINAPES
241 VVISGAQAAA NAIADRFAAQ GRRVHQLAVS HAFHSPLMEP MLEEFARVAA RVQAREPQLG
301 LVSNVTGELA GPDFGSAQYW VDHVRRPVRF ADSARHLQTL GATHFIEAGP GSGLTGSIEQ
361 SLAPAEAMVV SMLGKDRPEL ASALGAAGQV FTTGVPVQWS AVFAGSGGRR VQLPTYAFQR
421 RRFWETPGAD GPADAAGLGL GATEHALLGA VVERPDSDEV VLTGRLSLAD QPWLADHVVN
481 GVVLFPGAGF VELVIRAGDE VGCALIEELV LAAPLVMHPG VGVQVQVVVG AADESGHRAV
541 SVYSRGDQSQ GWLLNAEGML GVAAAETPMD LSVWPPEGAE SVDISDGYAQ LAERGYAYGP
601 AFQGLVAIWR RGSELFAEVV APGEAGVAVD RMGMHPAVLD AVLHALGLAV EKTQASTETR
661 LPFCWRGVSL HAGGAGRVRA RFASAGADAI SVDVCDATGL PVLTVRSLVT RPITAEQLRA
721 AVTAAGGASD QGPLEVVWSP ISVVSGGANG SAPPAPVSWA DFCAGSDGDA SVVVWELESA
781 GGQASSVVGS VYAATHTALE VLQSWLGADR AATLVVLTHG GVGLAGEDIS DLAAAAVWGM
841 ARSAQAENPG RIVLIDTDAA VDASVLAGVG EPQLLVRGGT VHAPRLSPAP ALLALPAAES
901 AWRLAAGGGG TLEDLVIQPC PEVQAPLQAG QVRVAVAAVG VNFRDVVAAL GMYPGQAPPL
961 GAEGAGVVLE TGPEVTDLAV GDAVMGFLGG AGPLAVVDQQ LVTRVPQGWS FAQAAAVPVV
1021 FLTAWYGLAD LAEIKAGESV LIHAGTGGVG MAAVQLARQW GVEVFVTASR GKWDTLRAMG
1081 FDDDHIGDSR TCEFEEKFLA VTEGRGVDVV LDSLAGEFVD ASLRLLVRGG RFLEMGKTDI
1141 RDAQEIAANY PGVQYRAFDL SEAGPARMQE MLAEVRELFD TRELHRLPVT TWDVRCAPAA
1201 FRFMSQARHI GKVVLTMPSA LADRLADGTV VITGATGAVG GVLARHLVGA YGVRHLVLAS
1261 RRGDRAEGAA ELAADLTEAG AKVQVVACDV ADRAAVAGLF AQLSREYPPV RGVIHAAGVL
1321 DDAVITSLTP DRIDTVLRAK VDAAWNLHQA TSDLDLSMFA LCSSIAATVG SPGQGNYSAA
1381 NAFLDGLAAH RQAAGLAGIS LAWGLWEQPG GMTAHLSSRD LARMSRSGLA PMSPAEAVEL
1441 FDAALAIDHP LAVATLLDRA ALDARAQAGA LPALFSGLAR RPRRRQIDDT GDATSSKSAL
1501 AQRLHGLAAD EQLELLVGLV CLQAAAVLGR PSAEDVDPDT EFGDLGFDSL TAVELRNRLK
1561 TATGLTLPPT VIFDHPTPTA VAEYVAQQMS GSRPTESGDP TSQVVEPAAA EVSVHA
//