LOCUS CCP45742.1 422 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Possible conserved polyketide
synthase associated protein PapA5 protein.
ACCESSION AL123456-3020
PROTEIN_ID CCP45742.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="papA5"
/locus_tag="Rv2939"
/note="Rv2939, (MTCY19H9.07), len: 422 aa. Possible
papA5,conserved polyketide synthase (PKS) associated
protein (see Camacho et al., 2001), equivalent to Q49939
hypothetical 45.6 KDA protein from Mycobacterium leprae
(423 aa), FASTA scores: opt: 2398, E(): 4.5e-144, (84.05%
identity in 426 aa overlap); and Q02279|YMA3_MYCBO
hypothetical 38.1 KDA protein from Mycobacterium bovis
(354 aa), FASTA scores: opt: 2193, E(): 3.6e-131, (97.4%
identity in 343 aa overlap). And C-terminus highly similar
to to Q9S381 hypothetical 5.0 KDA protein (fragment) from
Mycobacterium leprae (44 aa), FASTA scores: opt: 275, E():
1.4e-10,(88.65% identity in 44 aa overlap). Also similar
in part to various synthetases e.g. Q9AE01|RIF20 RIF20
protein from Amycolatopsis mediterranei (Nocardia
mediterranei) (403 aa), FASTA scores: opt: 282, E():
2.7e-10, (30.3% identity in 393 aa overlap); middle part
of Q00869|ESYN1 enniatin sythetase (fragment) (N-methyl
peptide synthetase) from Fusarium equiseti (3131 aa),
FASTA scores: opt: 180, E(): 0.0036, (26.85% identity in
242 aa overlap); N-terminus of Q9FB18 peptide synthetase
NRPS2-1 from Streptomyces verticillus (2626 aa), FASTA
scores: opt: 159, E(): 0.068,(23.65% identity in 351 aa
overlap); etc. Note that Rv2939|papA5 belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2939"
/db_xref="EnsemblGenomes-Tr:CCP45742"
/db_xref="GOA:P9WIN5"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR031641"
/db_xref="PDB:1Q9J"
/db_xref="UniProtKB/Swiss-Prot:P9WIN5"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MFPGSVIRKL SHSEEVFAQY EVFTSMTIQL RGVIDVDALS DAFDALLETH PVLASHLEQS
61 SDGGWNLVAD DLLHSGICVI DGTAATNGSP SGNAELRLDQ SVSLLHLQLI LREGGAELTL
121 YLHHCMADGH HGAVLVDELF SRYTDAVTTG DPGPITPQPT PLSMEAVLAQ RGIRKQGLSG
181 AERFMSVMYA YEIPATETPA VLAHPGLPQA VPVTRLWLSK QQTSDLMAFG REHRLSLNAV
241 VAAAILLTEW QLRNTPHVPI PYVYPVDLRF VLAPPVAPTE ATNLLGAASY LAEIGPNTDI
301 VDLASDIVAT LRADLANGVI QQSGLHFGTA FEGTPPGLPP LVFCTDATSF PTMRTPPGLE
361 IEDIKGQFYC SISVPLDLYS CAVYAGQLII EHHGHIAEPG KSLEAIRSLL CTVPSEYGWI
421 ME
//