LOCUS CCP45739.1 331 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Daunorubicin-dim-transport
ATP-binding protein ABC transporter DrrA protein.
ACCESSION AL123456-3017
PROTEIN_ID CCP45739.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="drrA"
/locus_tag="Rv2936"
/note="Rv2936, (MTCY19H9.04), len: 331 aa.
drrA,daunorubicin-dim-transport resistance ATP-binding
protein ABC transporter, probably involved in daunorubicin
resistance and phthiocerol dimycocerosate transport (see
citations below), equivalent to
Q49938|DRRA|ML2352|L518_F2_43|DRRA probable daunorubicin
resistance ATP-binding protein from Mycobacterium leprae
(331 aa), FASTA scores: opt: 1842, E(): 4.2e-103, (85.2%
identity in 331 aa overlap). Also highly similar to others
e.g. Q9XCF7 DRRA from Mycobacterium avium (315 aa), FASTA
scores: opt: 1040, E(): 4.7e-55, (54.35% identity in 309
aa overlap); Q9X5J8 daunorubicin resistance protein A from
Mycobacterium avium (315 aa), FASTA scores: opt: 1030,
E(): 1.9e-54, (53.7% identity in 309 aa overlap);
P32010|DRRA_STRPE daunorubicin resistance ATP-binding
protein from Streptomyces peucetius (330 aa), FASTA
scores: opt: 852, E(): 9e-44, (47.15% identity in 318 aa
overlap); etc. Contains PS00017 ATP/GTP-binding site motif
A (P-loop), and PS00211 ABC transporters family signature.
Belongs to the ATP-binding transport protein family (ABC
transporters). Note that Rv2936|drrA belongs to the
transcriptional unit Rv2930|fadD26-Rv2939|papA5 (proven
experimentally)."
/db_xref="EnsemblGenomes-Gn:Rv2936"
/db_xref="EnsemblGenomes-Tr:CCP45739"
/db_xref="GOA:P9WQL9"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005894"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="UniProtKB/Swiss-Prot:P9WQL9"
/inference="protein motif:PROSITE:PS00017"
/inference="protein motif:PROSITE:PS00211"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MRNDDMAVVV NGVRKTYGKG KIVALDDVSF KVRRGEVIGL LGPNGAGKTT MVDILSTLTR
61 PDAGSAIIAG YDVVSEPAGV RRSIMVTGQQ VAVDDALSGE QNLVLFGRLW GLSKSAARKR
121 AAELLEQFSL VHAGKRRVGT YSGGMRRRID IACGLVVQPQ VAFLDEPTTG LDPRSRQAIW
181 DLVASFKKLG IATLLTTQYL EEADALSDRI ILIDHGIIIA EGTANELKHR AGDTFCEIVP
241 RDLKDLDAIV AALGSLLPEH HRAMLTPDSD RITMPAPDGI RMLVEAARRI DEARIELADI
301 ALRRPSLDHV FLAMTTDPTE SLTHLVSGSA R
//