LOCUS       CCP45581.1               438 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Probable zinc protease
            PepR protein.
ACCESSION   AL123456-2859
PROTEIN_ID  CCP45581.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="pepR"
                     /locus_tag="Rv2782c"
                     /note="Rv2782c, (MTV002.47c), len: 438 aa. Probable
                     pepR,protease/peptidase, equivalent to
                     O32965|YR82_MYCLE|ML0855|MLCB22.26c hypothetical zinc
                     protease from Mycobacterium leprae (445 aa), FASTA scores:
                     opt: 2346, E(): 4.3e-146, (84.3% identity in 421 aa
                     overlap). Also highly similar to others e.g.
                     O86835|YA12_STRCO|SC9A10.02 from Streptomyces coelicolor
                     (459 aa), FASTA scores: opt: 1394, E(): 1.1e-83, (51.9%
                     identity in 416 aa overlap); Q04805|YMXG_BACSU|YMXG from
                     Bacillus subtilis (409 aa), FASTA scores: opt: 1014, E():
                     7.9e-59, (37.55% identity in 410 aa overlap);
                     Q9KA85|BH2405 from Bacillus halodurans (413 aa), FASTA
                     scores: opt: 967,E(): 9.6e-56, (38.6% identity in 417 aa
                     overlap); etc. Contains PS00143 Insulinase family,
                     zinc-binding region signature. Belongs to peptidase family
                     M16, also known as the insulinase family. Cofactor:
                     requires divalent cations for activity. Binds zinc.
                     Conserved in M. tuberculosis, M. leprae, M. bovis and M.
                     avium paratuberculosis; predicted to be essential for in
                     vivo survival and pathogenicity (See Ribeiro-Guimaraes and
                     Pessolani, 2007)."
                     /db_xref="EnsemblGenomes-Gn:Rv2782c"
                     /db_xref="EnsemblGenomes-Tr:CCP45581"
                     /db_xref="GOA:P9WHT5"
                     /db_xref="InterPro:IPR001431"
                     /db_xref="InterPro:IPR007863"
                     /db_xref="InterPro:IPR011249"
                     /db_xref="InterPro:IPR011765"
                     /db_xref="UniProtKB/Swiss-Prot:P9WHT5"
                     /inference="protein motif:PROSITE:PS00143"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MPRRSPADPA AALAPRRTTL PGGLRVVTEF LPAVHSASVG VWVGVGSRDE GATVAGAAHF
       61 LEHLLFKSTP TRSAVDIAQA MDAVGGELNA FTAKEHTCYY AHVLGSDLPL AVDLVADVVL
      121 NGRCAADDVE VERDVVLEEI AMRDDDPEDA LADMFLAALF GDHPVGRPVI GSAQSVSVMT
      181 RAQLQSFHLR RYTPERMVVA AAGNVDHDGL VALVREHFGS RLVRGRRPVA PRKGTGRVNG
      241 SPRLTLVSRD AEQTHVSLGI RTPGRGWEHR WALSVLHTAL GGGLSSRLFQ EVRETRGLAY
      301 SVYSALDLFA DSGALSVYAA CLPERFADVM RVTADVLESV ARDGITEAEC GIAKGSLRGG
      361 LVLGLEDSSS RMSRLGRSEL NYGKHRSIEH TLRQIEQVTV EEVNAVARHL LSRRYGAAVL
      421 GPHGSKRSLP QQLRAMVG
//