LOCUS CCP45579.1 371 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Secreted L-alanine dehydrogenase
Ald (40 kDa antigen) (TB43) protein.
ACCESSION AL123456-2857
PROTEIN_ID CCP45579.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="ald"
/locus_tag="Rv2780"
/note="Rv2780, (MT2850, MTV002.45), len: 371 aa.
Ald,secreted L-alanine dehydrogenase (40 kd antigen);
equivalent to Q9CBV6|ALD|ML1532 L-alanine dehydrogenase
from Mycobacterium leprae (371 aa), FASTA scores: opt:
2081, E(): 4e-115, (85.45% identity in 371 aa overlap).
Also highly similar to others e.g. Q9S227|SCI51.13c from
Streptomyces coelicolor (371 aa), FASTA scores: opt:
1575,E(): 2.3e-85, (66.05% identity in 371 aa overlap);
Q9K827|BH3180 from Bacillus halodurans (371 aa), FASTA
scores: opt: 1341, E(): 1.4e-71, (56.45% identity in 372
aa overlap); Q9RT70|DR1895 from Deinococcus radiodurans
(390 aa), FASTA scores: opt: 1319, E(): 2.8e-70, (54.2%
identity in 371 aa overlap); etc. Contains PS00836 and
PS00837 Alanine dehydrogenase & pyridine nucleotide
transhydrogenase signature 1 and 2. Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2780"
/db_xref="EnsemblGenomes-Tr:CCP45579"
/db_xref="GOA:P9WQB1"
/db_xref="InterPro:IPR007698"
/db_xref="InterPro:IPR007886"
/db_xref="InterPro:IPR008141"
/db_xref="InterPro:IPR008142"
/db_xref="InterPro:IPR008143"
/db_xref="InterPro:IPR036291"
/db_xref="PDB:2VHV"
/db_xref="PDB:2VHW"
/db_xref="PDB:2VHX"
/db_xref="PDB:2VHY"
/db_xref="PDB:2VHZ"
/db_xref="PDB:2VOE"
/db_xref="PDB:2VOJ"
/db_xref="UniProtKB/Swiss-Prot:P9WQB1"
/inference="protein motif:PROSITE:PS00836"
/inference="protein motif:PROSITE:PS00837"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MRVGIPTETK NNEFRVAITP AGVAELTRRG HEVLIQAGAG EGSAITDADF KAAGAQLVGT
61 ADQVWADADL LLKVKEPIAA EYGRLRHGQI LFTFLHLAAS RACTDALLDS GTTSIAYETV
121 QTADGALPLL APMSEVAGRL AAQVGAYHLM RTQGGRGVLM GGVPGVEPAD VVVIGAGTAG
181 YNAARIANGM GATVTVLDIN IDKLRQLDAE FCGRIHTRYS SAYELEGAVK RADLVIGAVL
241 VPGAKAPKLV SNSLVAHMKP GAVLVDIAID QGGCFEGSRP TTYDHPTFAV HDTLFYCVAN
301 MPASVPKTST YALTNATMPY VLELADHGWR AACRSNPALA KGLSTHEGAL LSERVATDLG
361 VPFTEPASVL A
//