LOCUS       CCP45563.1               263 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Probable thymidylate
            synthase ThyA (ts) (TSASE) protein.
ACCESSION   AL123456-2841
PROTEIN_ID  CCP45563.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="thyA"
                     /locus_tag="Rv2764c"
                     /note="Rv2764c, (MTV002.29c), len: 263 aa. Probable
                     thyA,thymidylate synthase, equivalent to
                     Q9CBW0|TYSY_MYCLE|THYA|ML1519 thymidylate synthase from
                     Mycobacterium leprae (266 aa), FASTA scores: opt:
                     1602,E(): 5.9e-102, (85.5% identity in 262 aa overlap).
                     Also highly similar to many e.g.
                     P00470|TYSY_ECOLI|B2827|Z4144|ECS3684|BAB37107|AAG57938
                     from Escherichia coli strains K12 and O157:H7 (264
                     aa),FASTA scores: opt: 1309, E(): 5.9e-82, (66.65%
                     identity in 261 aa overlap); P48464|TYSY_SHIFL|THYA from
                     Shigella flexneri (264 aa), FASTA scores: opt: 1303, E():
                     1.5e-81,(65.9% identity in 261 aa overlap);
                     P54081|TYSB_BACAM|THYB|THYBA from Bacillus
                     amyloliquefaciens (264 aa), FASTA scores: opt: 1235, E():
                     6.7e-77, (66.65% identity in 261 aa overlap); etc.
                     Contains PS00091 Thymidylate synthase active site. Belongs
                     to the thymidylate synthase family."
                     /db_xref="EnsemblGenomes-Gn:Rv2764c"
                     /db_xref="EnsemblGenomes-Tr:CCP45563"
                     /db_xref="GOA:P9WFR9"
                     /db_xref="InterPro:IPR000398"
                     /db_xref="InterPro:IPR020940"
                     /db_xref="InterPro:IPR023451"
                     /db_xref="InterPro:IPR036926"
                     /db_xref="PDB:3QJ7"
                     /db_xref="PDB:4FOA"
                     /db_xref="PDB:4FOG"
                     /db_xref="PDB:4FOX"
                     /db_xref="PDB:4FQS"
                     /db_xref="UniProtKB/Swiss-Prot:P9WFR9"
                     /inference="protein motif:PROSITE:PS00091"
BEGIN
        1 MTPYEDLLRF VLETGTPKSD RTGTGTRSLF GQQMRYDLSA GFPLLTTKKV HFKSVAYELL
       61 WFLRGDSNIG WLHEHGVTIW DEWASDTGEL GPIYGVQWRS WPAPSGEHID QISAALDLLR
      121 TDPDSRRIIV SAWNVGEIER MALPPCHAFF QFYVADGRLS CQLYQRSADL FLGVPFNIAS
      181 YALLTHMMAA QAGLSVGEFI WTGGDCHIYD NHVEQVRLQL SREPRPYPKL LLADRDSIFE
      241 YTYEDIVVKN YDPHPAIKAP VAV
//