LOCUS CCP45407.1 378 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Alpha-mannosyltransferase
PimA protein.
ACCESSION AL123456-2685
PROTEIN_ID CCP45407.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pimA"
/locus_tag="Rv2610c"
/note="Rv2610c, (MTCY01A10.23), len: 378 aa.
PimA,alpha-mannosyltransferase (see citations below),
equivalent to O07147|MLCL581.14c|ML0452 putative
glycosyltransferase from Mycobacterium leprae (374 aa),
FASTA scores: opt: 2044, E(): 8.8e-118, (82.25% identity
in 378 aa overlap). N-terminus (from aa 1 to 27)
equivalent to Q9FY7 putative alpha-mannosyl transferase
(fragment) from Mycobacterium smegmatis (27 aa), blastp
scores: 57.4 bits (137), E(): 3e-8, Identities = 25/27
(92%), Positives = 27/27 (99%) (see citation below). Also
highly similar to Q9L284|SCL2.15c putative sugar
transferase from Streptomyces coelicolor (387 aa), FASTA
scores: opt: 1222,E(): 1.8e-67, (52.95% identity in 376 aa
overlap); and similar in part to various proteins e.g.
Q9YA73|APE2066 long hypothetical
N-acetylglucosaminyl-phosphatidylinositol biosynthetic
protein from Aeropyrum pernix (392 aa), FASTA scores: opt:
434, E(): 3e-19, (31.5% identity in 378 aa overlap);
Q9UZA1|PAB0827 galactosyltransferase or LPS biosynthesis
RFBU related protein from Pyrococcus abyssi (371 aa),
FASTA scores: opt: 382, E(): 4.3e-16, (28.2% identity in
383 aa overlap); O26275|MTH173 LPS biosynthesis RFBU
related protein from Methanothermobacter
thermautotrophicus (382 aa), FASTA scores: opt: 372, E():
1.8e-15, (28.4% identity in 391 aa overlap); etc. Shows
also some similarity with O05313|Rv1212c|MTCI364.24c
hypothetical 41.5 KDA protein from Mycobacterium
tuberculosis (387 aa), FASTA scores: opt: 232, E(): 1.1e
-07, (28.4% identity in 402 aa overlap). Contains PS00017
ATP/GTP-binding site motif A (P-loop)."
/db_xref="EnsemblGenomes-Gn:Rv2610c"
/db_xref="EnsemblGenomes-Tr:CCP45407"
/db_xref="GOA:P9WMZ5"
/db_xref="InterPro:IPR028098"
/db_xref="UniProtKB/Swiss-Prot:P9WMZ5"
/inference="protein motif:PROSITE:PS00017"
BEGIN
1 MRIGMICPYS FDVPGGVQSH VLQLAEVMRT RGHLVSVLAP ASPHAALPDY FVSGGRAVPI
61 PYNGSVARLR FGPATHRKVK KWLAHGDFDV LHLHEPNAPS LSMLALNIAE GPIVATFHTS
121 TTKSLTLTVF QGILRPMHEK IVGRIAVSDL ARRWQMEALG SDAVEIPNGV DVDSFASAAR
181 LDGYPRQGKT VLFLGRYDEP RKGMAVLLDA LPKVVQRFPD VQLLIVGHGD ADQLRGQAGR
241 LAAHLRFLGQ VDDAGKASAM RSADVYCAPN TGGESFGIVL VEAMAAGTAV VASDLDAFRR
301 VLRDGEVGHL VPVDPPDLQA AALADGLIAV LENDVLRERY VAAGNAAVRR YDWSVVASQI
361 MRVYETVAGS GAKVQVAS
//