LOCUS CCP45243.1 172 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable resuscitation-
promoting factor RpfE protein.
ACCESSION AL123456-2521
PROTEIN_ID CCP45243.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="rpfE"
/locus_tag="Rv2450c"
/note="Rv2450c, (MTV008.06c), len: 172 aa. Probable
rpfE,resuscitation-promoting factor (see Mukamolova et
al.,1998), similar to O86308|Z96935|MLRPF_1 RPF protein
precursor from Micrococcus luteus (220 aa), FASTA scores:
opt: 291, E(): 3e-7, (48.75% identity in 80 aa overlap).
C-terminus is similar to other Mycobacterial rpf proteins
e.g. O05594|Rv1009|MTCI237.26|RPFB probable
resuscitation-promoting factor from Mycobacterium
tuberculosis (362 aa), FASTA scores: opt: 344, E():
1.4e-09, (42.85% identity in 147 aa overlap); etc.
C-terminal region similar to N-terminal region of
Q9F2Q2|SCE41.06c putative secreted protein from
Streptomyces coelicolor (244 aa), FASTA scores: opt:
355,E(): 3.1e-10, (56.65% identity in 90 aa overlap). Also
similar to Q9F2Q1|SCE41.07c putative secreted protein from
Streptomyces coelicolor (near Q9F2Q2|SCE41.06c) (341 aa)
FASTA scores: opt: 317, E(): 2.5e-08, (51.7% identity in
87 aa overlap). With Mycobacterium leprae, high similarity
between the two corresponding C-terminal regions of two
hypothetical proteins, Q9CD53|ML0240 (375 aa), FASTA
scores: opt: 339, E(): 2.5e-09, (59.15% identity in 93 aa
overlap) and O33049|MLCB57.05c|ML2151 (174 aa), FASTA
scores: opt: 329, E(): 4e-09, (58.14% identity in 86 aa
overlap). Contains a possible secretory signal sequence in
N-terminus. Possible autocrine and/or paracrine bacterial
growth factor or cytokine (see citations below). Interacts
with RipA (see Hett et al., 2007). Predicted possible
vaccine candidate (See Zvi et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2450c"
/db_xref="EnsemblGenomes-Tr:CCP45243"
/db_xref="GOA:O53177"
/db_xref="InterPro:IPR010618"
/db_xref="InterPro:IPR023346"
/db_xref="PDB:4CGE"
/db_xref="UniProtKB/Swiss-Prot:O53177"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MKNARTTLIA AAIAGTLVTT SPAGIANADD AGLDPNAAAG PDAVGFDPNL PPAPDAAPVD
61 TPPAPEDAGF DPNLPPPLAP DFLSPPAEEA PPVPVAYSVN WDAIAQCESG GNWSINTGNG
121 YYGGLRFTAG TWRANGGSGS AANASREEQI RVAENVLRSQ GIRAWPVCGR RG
//