LOCUS CCP45138.1 512 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Membrane-associated phospholipase
C 2 PlcB protein.
ACCESSION AL123456-2416
PROTEIN_ID CCP45138.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="plcB"
/gene_synonym="mpcB"
/locus_tag="Rv2350c"
/note="Rv2350c, (MT2415, MTCY98.19c), len: 512 aa. plcB
(alternate gene name: mpcB), membrane-associated
phospolipase C 2 (see citations below), similar to other
precursors of several phospolipases C e.g.
P15713|PHLN_PSEAE|PA3319 non-hemolytic phospholipase C
precursor from Pseudomonas aeruginosa (692 aa), FASTA
scores: opt: 885, E(): 2.3e-44, (38.5% identity in 525 aa
overlap); P06200|PHLC_PSEAE hemolytic phospholipase C
precursor from Pseudomonas aeruginosa (730 aa), FASTA
scores: opt: 639, E(): 6.3e-30, (537 aa overlap); Q9RGS8
non-hemolytic phospholipase C from Pseudomonas aeruginosa
(700 aa), FASTA scores: opt: 864, E(): 3.9e-43, (39.2%
identity in 528 aa overlap); etc. Also highly similar to
others from Mycobacterium tuberculosis e.g.
Q50560|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c phospholipase
C 1 (520 aa), FASTA scores: opt: 2788, E(): 4.5e-156,
(75.5% identity in 514 aa overlap);
Q9XB13|PLCD|Rv1755c|MT1799|MTCY28.21C phospholipase C 4
(514 aa), FASTA scores: opt: 2623, E(): 2.1e-146, (71.5%
identity in 512 aa overlap);
P95245|PLCC|Rv2349c|MT2414|MTCY98.18c phospholipase C 3
(508 aa), FASTA scores: opt: 2474, E(): 1.1e-137, (67.65%
identity in 513 aa overlap); etc. Belongs to the bacterial
phospholipase C family. Supposed membrane-associated, at
the extracellular side. Substrate of Tat pathway (See
McDonough et al., 2008)."
/db_xref="EnsemblGenomes-Gn:Rv2350c"
/db_xref="EnsemblGenomes-Tr:CCP45138"
/db_xref="GOA:P9WIB3"
/db_xref="InterPro:IPR006311"
/db_xref="InterPro:IPR007312"
/db_xref="InterPro:IPR017850"
/db_xref="UniProtKB/Swiss-Prot:P9WIB3"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MTRRQFFAKA AAATTAGAFM SLAGPIIEKA YGAGPCPGHL TDIEHIVLLM QENRSFDHYF
61 GTLSDTRGFD DTTPPVVFAQ SGWNPMTQAV DPAGVTLPYR FDTTRGPLVA GECVNDPDHS
121 WIGMHNSWNG GANDNWLPAQ VPFSPLQGNV PVTMGFYTRR DLPIHYLLAD TFTVCDGYFC
181 SLLGGTTPNR LYWMSAWIDP DGTDGGPVLI EPNIQPLQHY SWRIMPENLE DAGVSWKVYQ
241 NKLLGALNNT VVGYNGLVND FKQAADPRSN LARFGISPTY PLDFAADVRN NRLPKVSWVL
301 PGFLLSEHPA FPVNVGAVAI VDALRILLSN PAVWEKTALI VNYDENGGFF DHVVPPTPPP
361 GTPGEFVTVP DIDSVPGSGG IRGPIGLGFR VPCLVISPYS RGPLMVHDTF DHTSTLKLIR
421 ARFGVPVPNL TAWRDATVGD MTSTFNFAAP PNPSKPNLDH PRLNALPKLP QCVPNAVLGT
481 VTKTAIPYRV PFPQSMPTQE TAPTRGIPSG LC
//