LOCUS CCP44990.1 515 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Probable aminopeptidase PepB protein. ACCESSION AL123456-2268 PROTEIN_ID CCP44990.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="pepB" /locus_tag="Rv2213" /note="Rv2213, (MTCY190.24), len: 515 aa. Probable pepB,leucine aminopeptidase, similar to many e.g. SW:AMPA_ECOLI P11648 aminopeptidase a/I, (41.4% identity in 309 aa overlap). Equivalent to Z98741|MLCB22_6 Mycobacterium leprae cosmid B22; Am (524 aa), FASTA scores: opt: 2793,E(): 0; 83.1% identity in 522 aa overlap. Contains PS00631 Cytosol aminopeptidase signature, ntdaegrl. Conserved in M. tuberculosis, M. leprae, M. bovis and M. avium paratuberculosis; predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani, 2007)." /db_xref="EnsemblGenomes-Gn:Rv2213" /db_xref="EnsemblGenomes-Tr:CCP44990" /db_xref="GOA:P9WHT3" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="UniProtKB/Swiss-Prot:P9WHT3" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MTTEPGYLSP SVAVATSMPK RGVGAAVLIV PVVSTGEEDR PGAVVASAEP FLRADTVAEI 61 EAGLRALDAT GASDQVHRLA VPSLPVGSVL TVGLGKPRRE WPADTIRCAA GVAARALNSS 121 EAVITTLAEL PGDGICSATV EGLILGSYRF SAFRSDKTAP KDAGLRKITV LCCAKDAKKR 181 ALHGAAVATA VATARDLVNT PPSHLFPAEF AKRAKTLSES VGLDVEVIDE KALKKAGYGG 241 VIGVGQGSSR PPRLVRLIHR GSRLAKNPQK AKKVALVGKG ITFDTGGISI KPAASMHHMT 301 SDMGGAAAVI ATVTLAARLR LPIDVIATVP MAENMPSATA QRPGDVLTQY GGTTVEVLNT 361 DAEGRLILAD AIVRACEDKP DYLIETSTLT GAQTVALGTR IPGVMGSDEF RDRVAAISQR 421 VGENGWPMPL PDDLKDDLKS TVADLANVSG QRFAGMLVAG VFLREFVAES VDWAHIDVAG 481 PAYNTGSAWG YTPKGATGVP TRTMFAVLED IAKNG //