LOCUS CCP44885.1 291 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. protein. ACCESSION AL123456-2163 PROTEIN_ID CCP44885.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="prcB" /locus_tag="Rv2110c" /note="Rv2110c, (MTCY261.06c), len: 291 aa. PrcB,proteasome beta-type subunit 2. Conserved in M. tuberculosis, M. leprae, M. bovis and M. avium paratuberculosis; predicted to be essential for in vivo survival and pathogenicity (See Ribeiro-Guimaraes and Pessolani, 2007). prcBA genes encode a proteasome with broad substrate specificity (See Lin et al., 2006)." /db_xref="EnsemblGenomes-Gn:Rv2110c" /db_xref="EnsemblGenomes-Tr:CCP44885" /db_xref="GOA:P9WHT9" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022483" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:2FHG" /db_xref="PDB:2FHH" /db_xref="PDB:2JAY" /db_xref="PDB:3H6F" /db_xref="PDB:3H6I" /db_xref="PDB:3HF9" /db_xref="PDB:3HFA" /db_xref="PDB:3KRD" /db_xref="PDB:3MFE" /db_xref="PDB:3MI0" /db_xref="PDB:3MKA" /db_xref="PDB:5LZP" /db_xref="PDB:5THO" /db_xref="PDB:5TRG" /db_xref="PDB:5TRR" /db_xref="PDB:5TRS" /db_xref="PDB:5TRY" /db_xref="PDB:5TS0" /db_xref="PDB:6BGL" /db_xref="PDB:6BGO" /db_xref="UniProtKB/Swiss-Prot:P9WHT9" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MTWPLPDRLS INSLSGTPAV DLSSFTDFLR RQAPELLPAS ISGGAPLAGG DAQLPHGTTI 61 VALKYPGGVV MAGDRRSTQG NMISGRDVRK VYITDDYTAT GIAGTAAVAV EFARLYAVEL 121 EHYEKLEGVP LTFAGKINRL AIMVRGNLAA AMQGLLALPL LAGYDIHASD PQSAGRIVSF 181 DAAGGWNIEE EGYQAVGSGS LFAKSSMKKL YSQVTDGDSG LRVAVEALYD AADDDSATGG 241 PDLVRGIFPT AVIIDADGAV DVPESRIAEL ARAIIESRSG ADTFGSDGGE K //