LOCUS CCP44427.1 1602 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable polyketide synthase
Pks8 protein.
ACCESSION AL123456-1705
PROTEIN_ID CCP44427.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pks8"
/locus_tag="Rv1662"
/note="Rv1662, (MTCY275.01-MTCY06H11.27), len: 1602 aa.
Probable pks8, polyketide synthase, similar to many
polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide
synthase, modules 3 and 4 from Saccharopolyspora erythraea
(Streptomyces erythraeus) (3567 aa), FASTA scores: opt:
3319, E(): 0, (45.8% identity in 1619 aa overlap). Also
similar to other Mycobacterium tuberculosis probable
polyketide synthases e.g. pks7 and pks12. Contains PS00606
Beta-ketoacyl synthases active site and PS01162 Quinone
oxidoreductase/zeta-crystallin signature. Note that the
similarity extends into the downstream ORF Rv1663
(MTCY275.02), and this could be accounted for by a
frameshift, although the sequence has been checked and no
discrepancy was found."
/db_xref="EnsemblGenomes-Gn:Rv1662"
/db_xref="EnsemblGenomes-Tr:CCP44427"
/db_xref="GOA:O65933"
/db_xref="InterPro:IPR001227"
/db_xref="InterPro:IPR002364"
/db_xref="InterPro:IPR011032"
/db_xref="InterPro:IPR013149"
/db_xref="InterPro:IPR013154"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR014043"
/db_xref="InterPro:IPR015083"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR016036"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020801"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020843"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR042104"
/db_xref="UniProtKB/TrEMBL:O65933"
/inference="protein motif:PROSITE:PS00606"
/inference="protein motif:PROSITE:PS01162"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSGTTTHVDY LKRLTADLRR TRRRLSDLEA KLSEPVAVVG MGCRYPGGVD SPETLWELVA
61 QGRDAVSDFP ADRGWDVDGL FDPDPDACGK MYTRRGTFLE HAGDFDAGFF GIGPSEALAM
121 DPQQRLLLEV SWEALERTGI DPTKLRGSAT GVFAGVIHAG YGGQLSGELE GYGLTGSTLS
181 VASGRVAYVL GLEGPAVSVD TACSSSLVAL HLAVQSLRSG ECDLALAGGV TVMATPAAFV
241 EFSRQRALAR DGRCKVYAGA ADGTAWSEGA GVLVVERLVD ARRLGHPVLA LVRGSAVNQD
301 GASNGLTAPN GPSQQRVIRA ALASARLRAV EVDVVEGHGT GTMLGDPIEA QALLATYGQD
361 RVEPLWLGSI KSNIGHTSAA AGVAGVIKMV QAMRHGVMPK TLHVDVPTPH VDWSVGAVSL
421 LTQPRAWSVH GRPRRAGVSS FGISGTNAHV ILEQAPVVES VVPEVASPTA ASAVPWVLSA
481 RSEQALAGQA QRLLAFVAAN PDLDPIDVGW SLVKTRAMFE HRAVVVGADR GALLAGLAAL
541 AAGESGAGVA VGRARSVGKT VFVFPGQGAQ WVGMGAQLYA ELPLFALAFD AVAEELDRHL
601 RLPLRNVLWE GDEALLTSTE FAQPALFAIE VALATLLQHW GISPDFLIGH SVGEIAAAHL
661 AGVLSLTDAA GLVAARGRLM AELPAGGVMV VVAASEEEVL PVLVDGANLA AVNAPHSVVV
721 SGCEAAVSDI ADHFARRGRR VHRLAVSHAF HSLLMEPMLA EFTRIAAGIS VSKPRIPLVS
781 NVTGQMAGAG YGDGQYWVEH ARRPVRFAEG VQLLNAVGAT RFVEVGPGGG LTALVEQSLP
841 LGEALSVAMM RREHPEVSSV LGAVATLFTA GAQMDWPAVF GSPGRRIELP TYAFQRQRYW
901 LPPTSAGSAD ISGVGLLAAR HGLLGAVVEQ PDSDVVVLTG RLSVGEQRWL ADHVIAGVVL
961 LAGAAFVELA LRAADQVDCG VVEELTVVTP LVLPTVGGVQ LQVVVGVGEM GQRPVSIYSR
1021 NAESDSGWVL HARGVLGAKA VAPAADLSVW PPLGAAPVDV DGAYQRFAEL GYEYGRAFQG
1081 LTAMWRRESE LFADVAVPDD VDVTLSGFGI HPLVLDAALH AMGMVGEQAA TMLPFSWQGV
1141 SLHAAGASRV RARIAPAGDG TVSVELADQA GLPVLSVQAL VMRSVSSQLL SAAVAAADAA
1201 GRGLLEVAWL PVELAHNDIS ADLVVWELES FQDGVGPVYS ATHRVLVALQ SWLAQERAGR
1261 LVVLTQGSVG QDATNLAGAA VWGLVRSAQA EHPGRVMLVD SDGSMDVGDV IGCGEEQLMI
1321 RNGTAYAARL AQLRPQPILQ LPDTNSGWRL VAGGAGALED LTLASCPAKE LAPGQVRIEV
1381 RALGVNFRDV LVALGIYPGA AELGAEGAGV VTEVGPGVTG LAVGDPVMGL LGVAGSEAVV
1441 DARLVVKLPN RWPLTDAAGV PVVFLTAYYA LRVLAQVQPG ESVLVHAAAG GVGMAAVQLA
1501 RLWGLEVFAT ASRGKWDTLH TMGCDNTHVA DSRTLAFEET FWLTTEGRGV DVVLNSLAGE
1561 FTDASLRLLP RGGRFIEMGK TEFGTPRSLP RTILGWPTGL ST
//